Fig. 9

Change of relative bone volume at the affected area under different treatment modalities. Upper: Micro-CT (Computed Tomography) evaluation and radiographic examination. Lower: Systemic administration of vancomycin [VC (i.m.)] with/or without the presence of magnetic nanoparticles [VC (i.m.) + M] did not affect the bone volume change under peri-implent osteomyelitis condition; but, percent of bone volume (BV/TV) was significantly higher in the group of local administration of vancomycin into the femoral canal [VC (i.m.) + VC (f.c)] and the group when magnetic field was applied in the presence of magnetic nanoparticles [VC (i.m.) + M + IOHA]