Relationship between day 1 and day 2 Vancomycin area under the curve values and emergence of heterogeneous Vancomycin-intermediate Staphylococcus aureus (hVISA) by Etest® macromethod among patients with MRSA bloodstream infections: a pilot study

Table 3 Variables associated with emergence of hVISA in the multivariate analyses

	Variable	Relative Risk	95% confidence interval	P-value
Day 1	AUC_0-24h/MIC_BMD ≥ 521	0.14	0.03–0.60	0.008
	CL_CR	0.93	0.88–0.98	0.004
	Presence of IE	4.94	1.67–14.68	0.004
	Skin and soft tissue source	4.89	1.43–16.71	0.01
Day 2	AUC_24-48h/MIC_BMD ≥ 650	0.16	0.02–1.28	0.08
	CL_CR	0.95	0.91–0.98	0.007
	Presence of IE	4.62	1.67–12.77	0.003

Abbreviations: hVISA heterogeneous vancomycin-intermediate Staphylococcus aureus, AUC _0-24h /MIC _BMD area under the curve from 0 to 24 h over broth microdilution minimum inhibitory concentration, AUC _24-48h /MIC _BMD area under the curve from 24–48 h over broth microdilution minimum inhibitory concentration, IE infective endocarditis

ISSN: 1471-2334