Table 3 Discriminative capacitites of biomarkers for diagnosis of sepsis severity at days 1, 3 and 8 of ICU treatment, analyzed as area under the curves (AUCs (95% CI))

 ≥ Sepsis

 (n = 213)

0.92 (0.87–0.97)

p = 0.0001

0.91 (0.86–0.95)

p = 0.0001

0.92 (0.88–0.97)

p = 0.0001

0.82 (0.72–0.91)

p = 0.0001

0.59 (0.46–0.72)

p = 0.2

 Septic shock

 (n = 140)

0.81 (0.77–0.86)

p = 0.0001

0.81 (0.76–0.85)

p = 0.0001

0.79 (0.74–0.84)

p = 0.0001

0.61 (0.53–0.68)

p = 0.008

0.55 (0.47–0.62)

p = 0.2

 ≥ Sepsis

 (n = 154)

0.84 (0.79–0.90)

p = 0.0001

0.84 (0.78–0.89)

p = 0.0001

0.84 (0.78–0.90)

p = 0.0001

0.70 (0.60–0.79)

p = 0.0001

0.53 (0.42–0.63)

p = 0.6

 Septic shock

 (n = 80)

0.73 (0.67–0.80)

p = 0.0001

0.79 (0.73–0.85)

p = 0.0001

0.74 (0.68–0.80)

p = 0.0001

0.69 (0.61–0.76)

p = 0.001

0.54 (0.46–0.63)

p = 0.3

 ≥ Sepsis

 (n = 80)

0.82 (0.77–0.88)

p = 0.0001

0.83 (0.77–0.88)

p = 0.0001

0.79 (0.74–0.85)

p = 0.0001

0.74 (0.66–0.82)

p = 0.0001

0.66 (0.57–0.75)

p = 0.001

 Septic shock

 (n = 39)

0.79 (0.72–0.85)

p = 0.0001

0.81 (0.75–0.88)

p = 0.0001

0.81 (0.75–0.87)

p = 0.0001

0.70 (0.60–0.79)

p = 0.0001

0.74 (0.65–0.83)

p = 0.0001