Table 4 Diagnostic value of AST2/ALT to identify severe dengue based on AST & ALT upon admission
From: Evaluation of creatine kinase and liver enzymes in identification of severe dengue
Cutoff | Sensitivity % (95% CI) | Specificity% (95% CI) | PPV (95% CI) | NPV (95% CI) | Diagnostic accuracy (95% CI) | LR+ (95% CI) | LR– (95% CI) |
|---|---|---|---|---|---|---|---|
> 98.1 | 95.5 (77.2 - 99.9) | 40.5 (35.3 - 45.9) | 9.3 (6.2 - 13.9) | 99.3 (96.1 - 99.9) | 43.8 (38.8 - 49.0) | 1.6 (1.6 - 1.6) | 0.1 (0.02 - 0.8) |
> 402.5 | 59.1 (36.4 - 79.3) | 92.4 (89.1 - 95.0) | 33.3 (20.6 - 49.0) | 97.2 (94.8 - 98.5) | 90.4 (87.0 - 93.0) | 7.8 (6.5 - 9.3) | 0.4 (0.4 - 0.6) |
> 653.2 | 40.9 (20.7 - 63.7) | 97.4 (95.1 - 98.8) | 50.0 (29.0 - 71.0) | 96.3 (93.7 - 97.8) | 94.0 (91.0 - 96.0) | 15.6 (9.2 - 26.6) | 0.6 (0.5 - 0.7) |
> 1193 | 31.8 (13.9 - 54.9) | 99.4 (97.9 - 99.9) | 77.8 (45.3 - 93.7) | 95.8 (93.2 - 97.4) | 95.3 (92.7 - 97.1) | 54.6 (11.2 - 264.9) | 0.7 (0.6 - 0.8) |