Fig. 3

Distribution of pncA polymorphisms among the two largest MLVA clusters 94–32 and 100–32. Among all 57 strains with interpretable PZA DST results four clusters (94–32, 100–32, 407–32 and 1065–32) were identified. Clusters 407–32 and 1065–32 each consisted of two members, all carrying unique pncA mutations and are therefore not depicted in this figure. Distribution of strains with mutations in the pncA gene and their respective percentage in the cluster are listed. The legend indicates the position of the mutation in the pncA gene and the nucleotide change. In cluster 100–32 all but mutation A422C are present in individual isolates. No mutations are shared between the two clusters