Table 4 Efficacy and safety parameters (mean values ±standard deviation, median) at M6, M12 and M24 after initiation (baseline) of a RPV/TDF/FTC co-formulation among cART-naïve and cART-experienced patients
From: Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study
Baseline † | M6 †† | M12 ††† | M24 †††† | P value over time* | |
|---|---|---|---|---|---|
Viral load (copies/mL), n (%) | |||||
cART-naïve | |||||
<50 | 2 (4.2)¥ | 45 (93.8) | 41 (97.6) | 26 (100) | <0.001 |
> = 50 | 46 (95.8) | 3 (6.2) | 1 (2.4) | 0 (0) | |
cART-experienced | |||||
<50 | 549 (92.6) | 562 (96.2) | 514 (97.5) | 380 (96.7) | 0.002 |
> = 50 | 44 (7.4) | 22 (3.8) | 13 (2.5) | 13 (3.3) | |
CD4 count (cells/mm3), ±SD, median | |||||
cART-naïve | 478 (±176, 473) | 622 (±204, 602) | 621 (±201, 581) | 704 (±248, 649) | 0.004 |
cART-experienced | 650 (±273, 620) | 676 (±285, 643) | 681 (±286, 633) | 697 (±363, 660) | 0.001 |
ALAT (UI/L), ±SD, median | |||||
cART-naïve | 31 (±18, 28) | 31 (±16, 30) | 31 (±16, 28) | 30 (±14, 32) | 0.578 |
cART-experienced | 39 (±49, 29) | 38 (±42, 29) | 35 (±25, 29) | 36 (±63, 28) | 0.284 |
Creatinine (μmmol/L), ±SD, median | |||||
cART-naïve | 94 (±82, 82) | 88 (±15, 86) | 88 (±15, 86) | 91 (±13, 89) | 0.887 |
cART-experienced | 78 (±16, 77) | 85 (±18, 85) | 86 (±18, 86) | 85 (±21, 83) | <0.001 |
eGFR (mL/min/1.73m2), ±SD, median | |||||
cART-naïve | 98 (±25, 100) | 90 (±20, 89) | 91 (±21, 91) | 90 (±26, 86) | 0.008 |
cART-experienced | 100 (±25, 96) | 90 (±28, 86) | 88 (±23, 85) | 89 (±26, 87) | <0.001 |
Cholesterol (mmol/L), ±SD, median | |||||
cART-naïve | 4.7 (±1.0, 4.8) | 4.5 (±1.0, 4.4) | 4.5 (±1.0, 4.4) | NA | 0.270 |
cART-experienced | 5.1 (±1.0, 5.0) | 4.7 (±1.0, 4.6) | 4.7 (1.0, 4.6) | NA | <0.001 |
Triglycerides (mmol/L), ±SD, median | |||||
cART-naïve | 1.5 (±1.1, 1.2) | 1.5 (±1.1, 1.3) | 1.5 (±0.9, 1.4) | 1.3 (±0.6, 1.2) | 0.347 |
cART-experienced | 1.6 (±1.3, 1.3) | 1.4 (±0.9, 1.2) | 1.4 (±0.9, 1.2) | 1.4 (±0.9, 1.2) | <0.001 |
HDL-cholesterol (mmol/L), ±SD, median | |||||
cART-naïve | 1.2 (±0.4, 1.2) | 1.2 (±0.3, 1.2) | 1.1 (±0.3, 1.2) | NA | 0.195 |
cART-experienced | 1.3 (±0.4, 1.3) | 1.3 (±0.3, 1.2) | 1.2 (±0.3, 1.2) | NA | <0.001 |
BMI (kg/m2), ±SD, median | |||||
cART-naïve | 23.6 (±5.6, 22.6) | 24.2 (±3.8, 23.7) | 24.2 (±3.9, 23.8) | 22.9 (±1.0, 22.9) | 0.006 |
cART-experienced | 24.9 (±5.3, 24.4) | 24.7 (±4.0, 24.3) | 24.7 (±3.9, 24.3) | 24.8 (±4.6, 24.0) | 0.096 |