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Table 4 Risk factors for sepsis-attributable mortality in neonatal bloodstream infections with and without a focus of infection

From: Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Variables Univariate analysis Multivariate logistic regression analysis
Unadjusted OR (95% CI) P value Adjusted OR (95% CI) P value
Gestational age (weeks) 0.95 (0.90–1.01) 0.126 - -
Inappropriate antibiotics 1.64 (1.01–2.73) 0.048 1.05 (0.57–1.94) 0.872
Presence of infectious complications 6.19 (3.61–10.62) < 0.001 6.98 (3.64–13.39) < 0.001
Sequence of bloodstream infections
 1st episode 1 (reference)   1 (reference)  
 2nd episode 2.90 (1.57–5.41) 0.001 2.40 (1.21–4.74) 0.012
 3rd (or greater) episode 8.53 (4.63–15.71) < 0.001 7.40 (3.70–14.78) < 0.001
Underlying pulmonary hypertension 8.11 (3.58–18.35) < 0.001 4.77 (1.91–11.96) 0.001
Underlying neurological comorbidities 2.80 (1.59–4.93) < 0.001 1.89 (0.99–3.61) 0.053
BSIs with and without infectious focus
 Primary bacteremia 1 (reference)   - -
 With concurrent meningitis 1.05 (0.34–3.21) 0.937 - -
 With concurrent ventilator-associated pneumonia 1.27 (0.38–4.20) 0.699 - -
 With necrotizing enterocolitis 2.84 (0.64–12.57) 0.169 - -
 With concurrent CLABSIs 1.07 (0.34–3.75) 0.918 - -
  1. CLABSI central line-associated bloodstream infection, OR odds ratio, 95% CI 95% confidence interval