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Table 4 Risk factors for sepsis-attributable mortality in neonatal bloodstream infections with and without a focus of infection

From: Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Variables

Univariate analysis

Multivariate logistic regression analysis

Unadjusted OR (95% CI)

P value

Adjusted OR (95% CI)

P value

Gestational age (weeks)

0.95 (0.90–1.01)

0.126

-

-

Inappropriate antibiotics

1.64 (1.01–2.73)

0.048

1.05 (0.57–1.94)

0.872

Presence of infectious complications

6.19 (3.61–10.62)

< 0.001

6.98 (3.64–13.39)

< 0.001

Sequence of bloodstream infections

 1st episode

1 (reference)

 

1 (reference)

 

 2nd episode

2.90 (1.57–5.41)

0.001

2.40 (1.21–4.74)

0.012

 3rd (or greater) episode

8.53 (4.63–15.71)

< 0.001

7.40 (3.70–14.78)

< 0.001

Underlying pulmonary hypertension

8.11 (3.58–18.35)

< 0.001

4.77 (1.91–11.96)

0.001

Underlying neurological comorbidities

2.80 (1.59–4.93)

< 0.001

1.89 (0.99–3.61)

0.053

BSIs with and without infectious focus

 Primary bacteremia

1 (reference)

 

-

-

 With concurrent meningitis

1.05 (0.34–3.21)

0.937

-

-

 With concurrent ventilator-associated pneumonia

1.27 (0.38–4.20)

0.699

-

-

 With necrotizing enterocolitis

2.84 (0.64–12.57)

0.169

-

-

 With concurrent CLABSIs

1.07 (0.34–3.75)

0.918

-

-

  1. CLABSI central line-associated bloodstream infection, OR odds ratio, 95% CI 95% confidence interval