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Table 1 Summary of the characteristics of the 27 Klebsiella pneumoniae strains, including antimicrobial resistance profiles, resistance genes and MLST

From: Dissemination of Carbapenem-resistant Klebsiella pneumoniae clinical isolates with various combinations of Carbapenemases (KPC-2, NDM-1, NDM-4, and OXA-48) and 16S rRNA Methylases (RmtB and RmtC) in Vietnam

Strain MIC(mg/L) Carbapenemases Size of the plasmids harboring carbapenemase encoding genes ESBL 16S rRNA methylases Aminoglycoside modification enzymes Mutations in DNA gyrase MLST
ABK AMK AMP AZT CAZ CIP CSTa IPM MEM TGC gyrA parC
VNC Kp05 1024 >1024 >1024 512 256 256 4 (2) 8 8 1 OXA-48 50 kbp CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp10 256 512 >1024 1024 512 512 32 (2) 16 4 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB - S83Y, D87A S80I 15
VNC Kp13 256 1024 >1024 512 256 256 32 (2) 8 8 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp16 1024 >1024 >1024 512 256 512 32 (2) 8 4 2 OXA-48 50 kbp CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp17 512 >1024 >1024 512 128 256 4 (2) 8 8 4 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp20 512 >1024 >1024 256 128 256 0.25 2 8 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp21 256 1024 >1024 512 128 256 0.25 2 4 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp22 1024 1024 >1024 512 256 256 16 (2) 16 16 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp25 256 >1024 >1024 256 256 256 0.125 8 2 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp28 512 1024 >1024 512 256 256 8 (0.75) 8 8 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp29 1 4 >1024 512 32 32 0.125 4 4 1 KPC-2 150 kbp CTX-M-15, TEM-1, SHV-28 - AAC(6′)-Ib-cr S83I S80I 307
VNC Kp30 1 2 >1024 512 128 128 0.25 4 4 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 - AAC(6′)-Ib-cr, AADA16 APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp32 512 1024 >1024 1024 256 256 8 (1) 16 8 2 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp34 256 1024 >1024 512 256 256 32 (2) 8 8 1 OXA-48 ND CTX-M-15, SHV-28, TEM-1 RmtB AAC(6′)-Ib-cr, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp35 256 128 >1024 512 1024 256 16 (1) 8 8 2 OXA-48 ND CTX-M-14, SHV-12, TEM-1 RmtB AAC(6′)-Ib-cr, AADA1, APH(3′)-Ia S83Y, D87A S80I 15
VNC Kp39 >1024 >1024 >1024 32 >1024 256 0.5 8 8 1 NDM-1 100 kbp CTX-M-27, SHV-28 RmtC AAC(6′)-Ib-cr, AADA16 S83I S80I 395
VNC Kp42 16 16 >1024 256 >1024 64 32 (1) 32 64 1 NDM-4 120 kbp CTX-M-15, SHV-28, TEM-1 - AAC(6′)-Ib-cr, AADA1, AADA16 S83F, D87A S80I 15
VNC Kp43 1024 1024 >1024 512 256 256 0.25 4 4 2 OXA-48 ND CTX-M-14, SHV-12, TEM-1 RmtB AAC(6′)-Ib-cr, AADA1 S83Y, D87A S80I 15
VNC Kp51 16 16 >1024 1024 256 64 0.25 16 4 1 OXA-48 ND CTX-M-14, SHV-12, TEM-1 - AAC(6′)-Ib-cr, AADA1 S83Y, D87A S80I 15
VNC Kp54 >1024 >1024 >1024 1024 256 64 0.5 8 16 1 OXA-48 145.5 kbp CTX-M-14, CTX-M-15, SHV-1, TEM-1 RmtB AADA2, APH(3′)-Ia S83F, D87N E84K 16
VNC Kp56 >1024 >1024 >1024 512 256 64 0.25 16 16 1 OXA-48 ND CTX-M-14, CTX-M-15, SHV-1, TEM-1 RmtB AADA2, APH(3′)-Ia S83F, D87N E84K 16
VNC Kp57 >1024 >1024 >1024 64 >1024 256 0.25 64 128 0.5 NDM-4 40 kbp CTX-M-27, SHV-11, TEM-1 RmtB - S83I S80I 2353
VNC Kp68 2 4 >1024 512 256 64 0.125 4 8 2 OXA-48 50 kbp SHV-1, TEM-1 - AAC(6′)-Ib-cr S83I S80I 147
VNC Kp70 16 16 >1024 1024 >1024 256 0.125 128 256 2 NDM-4 120 kbp CTX-M-14, CTX-M-15, SHV-1, TEM-1 - AAC(6′)-Ib-cr, AADA1, AADA2 S83F, D87N E84K 16
VNC Kp72 16 8 >1024 128 >1024 128 0.125 32 64 2 NDM-4 ND CTX-M-15, SHV-28, TEM-1 - AAC(6′)-Ib-cr, AADA1, AADA16 S83F, D87A S80I 15
VNC Kp73 16 16 >1024 1024 >1024 512 0.125 128 256 2 NDM-4 ND CTX-M-14, CTX-M-15, SHV-1, TEM-1 - AAC(6′)-Ib-cr, AADA1, AADA2 S83F, D87N E84K 16
VNC Kp77 >1024 >1024 >1024 128 >1024 256 0.25 16 64 1 NDM-1 ND CTX-M-27, SHV-28 RmtC AAC(6′)-Ib-cr, AADA16 S83I S80I 395
  1. MIC, minimum inhibitory concentration, ABK arbekacin, AMK amikacin, AMP ampicillin, AZT azidothymidine, CAZ ceftazidime, CIP ciprofloxacin, CST colistin, IPM imipenem, MEM meropenem, TGC tigecycline, ESBL extended-spectrum-lactamase, ND not determined
  2. aMICs for colistin using Etest are given in parentheses