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Table 3 Initial antifungal therapy and outcomes of 26 patients with CNS involvement

From: Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital

Variables

No. (%) of patients (N = 26)

Initial antifungal therapy

 AmB based

18 (69.2)

 Fluconazole based

5 (19.2)

 Othera

3 (11.6)

Efficacy of initial antifungal therapy

 Success

11 (42.3)

  Complete response

0

  Partial response

11 (42.3)

 Failure

15 (57.7)

  Stable

10 (38.5)

  Progression

1 (3.8)

  Death

4 (15.4)

 Outcomeb

 2-week mortality rate

3/26 (11.6%)

 10-week mortality rate

5/25 (20.0%)

 1-year survival rate

18/25 (72.0%)

  1. CNS central nervous system; AmB amphotericin B
  2. aOther initial antifungal therapies included voriconazole in 2, itraconazole in 1 patient
  3. bOne patient lost for 10-week and 1-year follow-up