Skip to main content

Table 2 Clinical manifestations and laboratory findings of 33 patients

From: Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital

Variables

Patients with CNS involvement (N = 26)

Patients without CNS involvement (N = 7)

Manifestations, n (%)

 Fever

24 (92.3)

1 (14.3)

 Headache

24 (92.3)

0

 Vomiting

11 (42.3)

0

 Meningeal irritation signs

8 (30.8)

0

 Coma

7 (26.9)

0

 Epilepsy

7 (26.9)

0

 Hearing loss

3 (11.5)

0

 Blurred vision

2 (7.7)

0

 Cough

2 (7.7)

3 (42.9)

 Shortness of breath

0

1 (14.3)

 Asymptomatic

0

4 (57.1)

 Other symptomsa

3 (11.5)

0

Baseline CSF parameters

 Opening Pressure, mmH2Ob

>300 (120, >300)

113 (75, 260)

 WBC, cells/mm3c

28 (1, 533)

2 (1, 7)

 Protein, g/Ld

0.77 (0.18, 2.6)

0.28 (0.16, 0.73)

 Glucose, mmol/Le

1.6 (0.14, 5.32)

3.2 (2.8, 3.9)

 CrAg titerf

1:1280 (1:640, >1:1280)

All negative

 Indian ink smear, +/−g

23/2

0/7

 Culture for Cryptococcus, +/−h

17/3

0/7

Baseline serum CrAg titeri

1:1280 (1:640, 1:5120)

1:10 (Negative, 1:640)

  1. CNS central nervous system; CSF cerebrospinal fluid; WBC white blood cell count; CrAg cryptococcal antigen
  2. aOther symptoms included blindness in 1, loss of recent memory in 1 and symptoms of brain stem herniation in 1
  3. bCSF opening pressure was not documented in 5 CNS infected patients and 2 CNS uninfected patients
  4. cCSF WBC was not documented in 6 CNS infected patients
  5. dCSF protein was not documented in 4 CNS infected patients
  6. eCSF glucose was not documented in 4 CNS infected patients
  7. fCSF CrAg was not documented in 5 CNS infected patients. In 1 patient, CSF CrAg was positive, but titer was not recorded
  8. gCSF Indian ink smear was not documented in 1 CNS infected patient
  9. hCSF culture for Cryptococcus was not documented in 6 CNS infected patients
  10. iSerum CrAg titer was not documented in 11 CNS infected patients