Variables | Patients with CNS involvement (N = 26) | Patients without CNS involvement (N = 7) |
---|---|---|
Manifestations, n (%) | ||
Fever | 24 (92.3) | 1 (14.3) |
Headache | 24 (92.3) | 0 |
Vomiting | 11 (42.3) | 0 |
Meningeal irritation signs | 8 (30.8) | 0 |
Coma | 7 (26.9) | 0 |
Epilepsy | 7 (26.9) | 0 |
Hearing loss | 3 (11.5) | 0 |
Blurred vision | 2 (7.7) | 0 |
Cough | 2 (7.7) | 3 (42.9) |
Shortness of breath | 0 | 1 (14.3) |
Asymptomatic | 0 | 4 (57.1) |
Other symptomsa | 3 (11.5) | 0 |
Baseline CSF parameters | ||
Opening Pressure, mmH2Ob | >300 (120, >300) | 113 (75, 260) |
WBC, cells/mm3c | 28 (1, 533) | 2 (1, 7) |
Protein, g/Ld | 0.77 (0.18, 2.6) | 0.28 (0.16, 0.73) |
Glucose, mmol/Le | 1.6 (0.14, 5.32) | 3.2 (2.8, 3.9) |
CrAg titerf | 1:1280 (1:640, >1:1280) | All negative |
Indian ink smear, +/−g | 23/2 | 0/7 |
Culture for Cryptococcus, +/−h | 17/3 | 0/7 |
Baseline serum CrAg titeri | 1:1280 (1:640, 1:5120) | 1:10 (Negative, 1:640) |