Pf isolate
|
Clinical status
|
Number of pRBC adhered per 700 cells
|
Mean OD direct contact mediated apoptosis (SD)
|
Mean OD soluble factor mediated apoptosis (SD)
|
---|
hCMEC/D3
|
HLEC
|
HLEC
|
hCMEC/D3
|
HLEC
|
hCMEC/ D3
|
---|
F1
|
UN
|
1
|
641
|
0.99 (0.05)
|
9.08 (0.05)
|
2.23 (0.09)
|
8.04 (0.61)
|
F2
|
UN
|
1
|
1
|
1.57 (0.12)
|
8.73 (0.62)
|
0.83 (0.04)
|
5.41 (0.07)
|
F3
|
UN
|
25
|
41
|
0.86 (0.04)
|
1.12 (0.09)
|
0.71 (0/09)
|
0.46 (0.05)
|
3D71
|
-
|
254
|
415
|
3.15
|
3.79
|
1.25
|
4.52
|
RBC1
|
-
|
1
|
0
|
0.39
|
0.49
|
0.25
|
0.41
|
F4
|
UN
|
3152
|
201
|
2.79 (0.07)
|
1.68 (0.14)
|
0.74 (0.04)
|
0.93 (0.05)
|
F5
|
UN
|
806
|
54
|
1.79 (0.08)
|
1.57 (0.11)
|
0.62 (0.02)
|
0.63 (0.18)
|
3D72
|
-
|
279
|
361
|
3.65
|
3.21
|
1.05
|
4.02
|
RBC2
|
-
|
3
|
8
|
0.67
|
0.23
|
0.42
|
0.29
|
F15
|
UN
|
69
|
81
|
6.39 (0.46)
|
11.37 (0.21)
|
2.23 (0.07)
|
8.59 (0.23)
|
F16
|
UN
|
3
|
9
|
1.00 (0.04)
|
0.68 (0.09)
|
0.41 (0.05)
|
1.70 (0.11)
|
F17
|
UN
|
9
|
41
|
0.82 (0.09)
|
0.84 (0.04)
|
0.73 (0.04)
|
8.73 (0.69)
|
3D73
|
-
|
291
|
541
|
3.19
|
3.52
|
1.88
|
4.45
|
RBC3
|
-
|
0
|
0
|
0.95
|
0.32
|
0.89
|
0.48
|
F19
|
UN
|
7
|
11
|
0.71 (0.03)
|
0.69 (0.06)
|
0.60 (0.05)
|
9.08 (0.09)
|
3D74
|
-
|
213
|
245
|
3.43
|
3.91
|
1.25
|
4.58
|
RBC4
|
-
|
10
|
6
|
0.20
|
0.88
|
0.11
|
0.61
|
F20
|
UN
|
51
|
157
|
2.55 (0.08)
|
0.92 (0.13)
|
0.63 (0.04)
|
0.54 (0.06)
|
F21
|
UN
|
0
|
1
|
2.07 (0.09)
|
0.95 (0.06)
|
1.56 (0.30)
|
0.59 (0.08)
|
F23
|
UN
|
5
|
54
|
2.87 (0.09)
|
0.89 (0.01)
|
1.09 (0.06)
|
0.74 (0.03)
|
3D75
|
-
|
259
|
354
|
3.00
|
3.25
|
1.56
|
4.12
|
RBC5
|
-
|
2
|
2
|
0.38
|
0.14
|
0.46
|
0.23
|
F25a
|
SM
|
5040
|
2340
|
0.40 (0.12)
|
0.74 (0.04)
|
1.20 (0.10)
|
0.55 (0.04)
|
F26b
|
SM
|
1
|
3
|
2.08 (0.19)
|
3.09 (0.06)
|
3.48 (0.03)
|
1.88 (0.15)
|
F27
|
UN
|
1652
|
224
|
0.63 (0.04)
|
0.32 (0.11)
|
1.09 (0.11)
|
0.66 (0.04)
|
F28
|
UN
|
3
|
5
|
2.07 (0.09)
|
0.42 (0.04)
|
3.53 (0.08)
|
0.88 (0.16)
|
3D76
|
-
|
368
|
463
|
3.65
|
4.01
|
1.12
|
4.85
|
RBC6
|
-
|
3
|
2
|
0.52
|
0.26
|
0.44
|
0.31
|
F29
|
UN
|
231
|
87
|
2.07 (0.10)
|
1.62 (0.06)
|
3.40 (0.10)
|
3.81 (0.11)
|
F30
|
UN
|
473
|
286
|
4.12 (0.14)
|
5.43 (0.26)
|
1.97 (0.04)
|
8.68 (0.13)
|
F31
|
UN
|
337
|
307
|
0.38 (0.12)
|
1.30 (0.34)
|
4.87 (0.10)
|
6.75 (0.18)
|
F33
|
UN
|
7
|
31
|
1.46 (0.09)
|
4.74 (0.20)
|
2.49 (0.06)
|
1.74 (0.05)
|
3D77
|
-
|
363
|
435
|
3.02
|
3.85
|
1.00
|
5.24
|
RBC7
|
-
|
0
|
1
|
0.54
|
0.45
|
0.35
|
0.15
|
F34
|
UN
|
10
|
67
|
1.10 (0.07)
|
2.23 (0.14)
|
1.84 (0.08)
|
2.73 (0.05)
|
F32
|
UN
|
70
|
157
|
1.05 (0.07)
|
4.32 (0.17)
|
1.07 (0.05)
|
1.91 (0.11)
|
3D78
|
-
|
440
|
522
|
3.75
|
4.12
|
1.89
|
5.87
|
RBC8
|
-
|
1
|
1
|
0.23
|
0.46
|
0.23
|
0.31
|
F35
|
UN
|
180
|
101
|
1.78 (0.11)
|
1.44 (0.10)
|
1.76 (0.14)
|
4.47 (0.09)
|
F36
|
UN
|
7
|
11
|
0.94 (0.07)
|
1.67 (0.08)
|
0.99 (0.01)
|
5.92 (0.09)
|
F37
|
UN
|
3
|
2
|
3.39 (0.30)
|
3.00 (0.15)
|
2.23 (0.04)
|
6.72 (0.10)
|
3D79
|
-
|
304
|
354
|
3.15
|
3.82
|
1.46
|
4.54
|
RBC9
|
-
|
3
|
0
|
0.65
|
0.24
|
0.69
|
0.36
|
F39
|
UN
|
1
|
21
|
1.57 (0.12)
|
1.53 (0.07)
|
0.44 (0.06)
|
1.03 (0.05)
|
F40
|
UN
|
70
|
196
|
3.79 (0.14)
|
3.50 (0.05)
|
0.50 (0.04)
|
0.99 (0.01)
|
3D710
|
-
|
343
|
398
|
3.05
|
3.81
|
0.96
|
4.21
|
RBC10
|
-
|
-
|
-
|
0.52
|
0.26
|
0.66
|
0.17
|
-
Pf P. falciparum, UN uncomplicated malaria, SM severe malaria. The number of adherent pRBC was determined microscopically; OD optical density. The mean OD was determined for each isolate. Using a positivity cut-off of 3; 3D71: positive control for the first experiment. 3D72.3.…10: positive control for the remaining experiments; RBC1: negative control for the first experiment. RBC2.3.…10: negative control for the remaining experiments
-
aPatient with convulsions
-
bPatient with prostration