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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co-cultured with Plasmodium falciparum field isolates

Fig. 2

PRBC-mediated EC apoptosis. a) PRBC-mediated EC apoptosis by direct contact with and without cytoadherence

The ability of field isolates to induce EC apoptosis was the same for hCMEC/D3 (9 apoptogenic PRBCs) and HLEC (4 apoptogenic PRBCs) (p > 0.05) and the mean optical density was also similar (p > 0.05); b) PRBC-mediated EC apoptosis by release of soluble factors. hCMEC/D3 were more susceptible to apoptosis mediated by soluble factors (11 apoptogenic PRBCs) than were HLEC (4 apoptogenic PRBCs) (p < 0.05) but intensity (mean OD ratio) of this apoptosis was higher with hCMEC/D3 (p < 0.01). P. falciparum field isolates trigger cerebral cells apoptosis than lung cells (p < 0.01)

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BMC Infectious Diseases

ISSN: 1471-2334

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