Table 3 Baseline variables associated with significant fibrosis (Fibroscan >7.9 kPa) among Ethiopian patients with chronic hepatitis B (n = 260)
No fibrosis N (%) | Significant fibrosis N (%) | Crude | Adjusted | |||
|---|---|---|---|---|---|---|
Baseline variable | OR (95% CI) | P | OR (95% CI) | P | ||
Gender | ||||||
Female | 99 (53.2) | 17 (23.0) | 1 | 1 | ||
Male | 87 (46.8) | 57 (77.0) | 3.8 (2.1–7.0) | <0.001 | 3.0 (1.5–5.9) | 0.002 |
Age group (years) | ||||||
18–25 | 41 (22.0) | 12 (16.2) | 1 | 1 | ||
26–35 | 92 (49.5) | 23 (31.1) | 0.9 (0.4–1.9) | 0.695 | 1.5 (0.6–3.9) | 0.406 |
36–45 | 30 (16.1) | 22 (29.7) | 2.5 (1.1–5.8) | 0.033 | 4.4 (1.5–12.8) | 0.006 |
> 45 | 23 (12.4) | 17 (23.0) | 2.5 (1.0–6.2) | 0.043 | 3.6 (1.2–11.0) | 0.022 |
Alcohol abuse | ||||||
No | 184 (98.9) | 71 (95.9) | 1 | |||
Yes | 2 (1.1) | 3 (4.1) | 3.9 (0.6–23.8) | 0.142 | ||
HBeAg (n = 255) | ||||||
Negative | 174 (95.1) | 60 (83.3) | 1 | 1 | ||
Positive | 9 (4.9) | 12 (16.7) | 3.9 (1.6–9.6) | 0.004 | 2.7 (0.9–8.4) | 0.087 |
HBV genotype (n = 68) | ||||||
A | 38 (82.6) | 19 (86.4) | 1 | |||
D | 8 (17.4) | 3 (13.6) | 0.8 (0.2–3.2) | 0.695 | ||
HDV co-infection (n = 259) | ||||||
No | 180 (97.3) | 72 (97.3) | 1 | |||
Yes | 5 (2.7) | 2 (2.7) | 1.0 (0.2–5.3) | 1.000 | ||
ALT (U/L) | ||||||
≤ 40 | 166 (89.2) | 56 (75.7) | 1 | 1 | ||
> 40 | 20 (10.8) | 18 (24.3) | 2.7 (1.3–5.4) | 0.006 | 1.8 (0.8–4.0) | 0.162 |
HBV viral load (IU/ml) (n = 259) | ||||||
< 2000 | 114 (61.6) | 37 (50.0) | 1 | 1 | ||
2000–19,999 | 47 (25.4) | 9 (12.2) | 0.6 (0.3–1.3) | 0.198 | 0.7 (0.3–1.6) | 0.350 |
≥ 20,000 | 24 (13.0) | 28 (37.8) | 3.6 (1.9–7.0) | <0.001 | 3.2 (1.4–7.4) | 0.006 |