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Table 1 Patient characteristics

From: Development and validation of a prognostic scoring model for Mycobacterium avium complex lung disease: an observational cohort study

 

Cohort 1, N = 368

Cohort 2, N = 118

P-value

Male

151 (41.0)

45 (38.1)

0.592

Age, years

72 ± 10

70 ± 10

0.019

Smoking history

  

0.264

 Current

20 (5.4)

4 (3.4)

 

 Past

224 (60.9)

76 (64.4)

 

 Never

114 (31.0)

38 (32.2)

 

 Unknown

10 (2.7)

0 (0.0)

 

Comorbidity

 Respiratory diseases

110 (29.9)

41 (34.7)

0.361

  Old pulmonary tuberculosis

31 (8.4)

24 (20.3)

0.001

  Emphysema

40 (10.9)

14 (11.9)

0.739

  Interstitial pneumonia

29 (7.9)

6 (5.1)

0.413

  Lung cancer

31 (8.4)

6 (5.1)

0.318

  Asthma

12 (3.3)

6 (5.1)

0.402

  Bronchiectasis

20 (5.4)

5 (4.2)

0.811

 Systemic diseases

  Chronic heart diseases

45 (12.2)

18 (15.3)

0.431

  Diabetes mellitus

40 (10.9)

10 (8.5)

0.492

  Collagen vascular diseases

27 (7.3)

13 (11.0)

0.247

  Malignancya

86 (23.4)

27 (22.9)

0.999

  Chronic liver diseases

8 (2.2)

6 (5.1)

0.115

  Neurological diseases

33 (9.0)

12 (10.2)

0.716

  Chronic renal diseases

7 (1.9)

9 (7.6)

0.005

Steroid use

14 (3.8)

7 (6.0)

0.306

Immunosuppressant useb

19 (5.2)

5 (4.3)

0.811

BMI, kg/m2

19.6 ± 3.4

20.3 ± 3.2

0.090

BT, °C

36.7 ± 0.6

36.7 ± 0.9

0.735

Laboratory findings

 Lymphocytes,/μL

1400 ± 680

1300 ± 480

0.014

 Hb, g/dL

12.4 ± 1.8

13 ± 1.6

0.001

 Alb, g/dL

3.9 ± 0.6

4.2 ± 0.4

<0.001

 CRP, mg/dL

1.7 ± 3.5

3.7 ± 7.4

<0.001

 Cre, mg/dL

0.79 ± 0.73

0.9 ± 0.99

0.206

Diagnosis methods

  

<0.001

 Sputum

263 (71.5)

115 (97.5)

 

 Bronchoscopy

105 (28.5)

3 (2.5)

 

Bacteriological examinations

 Smear positive

64 (17.4)

38 (32.2)

0.001

 Culture ≥2+

74 (20.1)

NE

 

 Macrolide resistant

0 (0.0)

0 (0.0)

NE

Radiological findings

  

0.337

 NB

298 (81.0)

101 (85.6)

 

 FC

41 (11.1)

14 (11.9)

 

 FC/NB

6 (1.6)

0 (0.0)

 

 Otherc

35 (9.5)

3 (2.5)

 

Deaths

75 (20.5)

20 (16.9)

0.505

Causes of death

  

0.864

 MAC-specific death

29 (38.7)

9 (45.0)

 

 Malignancy

20 (26.7)

4 (20.0)

 

 Other

20 (26.7)

5 (25.0)

 

 Unknown

6 (0.1)

1 (5.0)

 
  1. Data are n (%) or mean ± standard deviation
  2. BMI body mass index, BT body temperature, Hb hemoglobin, Alb serum albumin, CRP C-reactive protein, Cre creatinine, NE not evaluated, NB nodular/bronchiectatic disease, FC fibrocavitary disease
  3. aMalignancy includes lung cancer
  4. bImmunosuppressants included methotrexate, cyclosporin, azathioprine, cyclophosphamide, tacrolimus, etanercept, salazopyrin, mizoribine, and bucillamine
  5. cOther included unclassifiable and disseminated diseases