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Table 4 Validation of optimal risk score E.a in MACS, 1984–2010

From: Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men

Cutoffb

Sensitivity %

Specificity %

Positive LR

Negative LR

% to be tested

≥ 0.9

85.4

53.0

1.8

0.3

47.2

≥ 1.1

67.2

72.3

2.4

0.5

27.9

≥ 1.5

56.2

88.8

5.0

0.5

11.4

≥ 1.6

51.8

89.9

5.1

0.5

10.3

≥ 1.7

48.9

90.7

5.3

0.6

9.5

≥ 1.8

48.9

90.9

5.4

0.6

9.3

≥ 2.0

48.8

91.1

5.4

0.6

9.1

≥ 2.4

28.5

97.1

9.8

0.7

3.0

  1. LR likelihood ratio, MACS Multicenter AIDS Cohort Study
  2. aIncluding 4 symptoms and 3 risk factors (Table 3, row 7): fever, lymphadenopathy, oral thrush, weight loss, gonorrhea, receptive condomless anal intercourse, >5 sexual partners
  3. bCutoff levels were defined by each possible sum of the score of symptoms and risk factors, based on the beta coefficient (Table 3, column 8)