TY - JOUR AU - Eljaaly, Khalid AU - Alshehri, Samah AU - Aljabri, Ahmed AU - Abraham, Ivo AU - Al Mohajer, Mayar AU - Kalil, Andre C. AU - Nix, David E. PY - 2017 DA - 2017/06/02 TI - Clinical failure with and without empiric atypical bacteria coverage in hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis JO - BMC Infectious Diseases SP - 385 VL - 17 IS - 1 AB - Both typical and atypical bacteria can cause community-acquired pneumonia (CAP); however, the need for empiric atypical coverage remains controversial. Our objective was to evaluate the impact of antibiotic regimens with atypical coverage (a fluoroquinolone or combination of a macrolide/doxycycline with a β-lactam) to a regimen without atypical antibiotic coverage (β-lactam monotherapy) on rates of clinical failure (primary endpoint), mortality, bacteriologic failure, and adverse events, (secondary endpoints). SN - 1471-2334 UR - https://doi.org/10.1186/s12879-017-2495-5 DO - 10.1186/s12879-017-2495-5 ID - Eljaaly2017 ER -