Table 4 Pattern of gene mutations detected by the MTBDRplus assay in 60 drug-resistant Mycobacterium tuberculosis isolates
Gene | Band | Gene region or mutations | aINH monoresistant NĀ =Ā 6 | aINH poly-resistant NĀ =Ā 5 | aMDR-TB (NĀ =Ā 49) |
|---|---|---|---|---|---|
rpoB | |||||
| Ā | WT1 | 506ā509 | 6 | 5 | 49 |
| Ā | WT2 | 510ā513 | 6 | 5 | 48 |
| Ā | WT3 | 513ā517 | 6 | 5 | 46 |
| Ā | WT4 | 516ā519 | 6 | 5 | 47 |
| Ā | WT5 | 518ā522 | 6 | 5 | 49 |
| Ā | WT6 | 521ā525 | 6 | 5 | 49 |
| Ā | WT7 | 526ā529 | 6 | 5 | 46 |
| Ā | WT8 | 530ā533 | 6 | 5 | 7 |
| Ā | MUT1 | D516V | 0 | 0 | 0 |
| Ā | MUT2A | H526Y | 0 | 0 | 0 |
| Ā | MUT2B | H526D | 0 | 0 | 3 |
| Ā | MUT3 | S531L | 0 | 0 | 41 |
KatG | |||||
| Ā | WT | 315 | 5 | 1 | 19 |
| Ā | MUT1 | S315T1 | 1 | 4 | 30 |
| Ā | MUT2 | S315T2 | 0 | Ā | 0 |
inhA | |||||
| Ā | WT1 | -15/ā16 | 3 | 5 | 32 |
| Ā | WT2 | -8 | 6 | 5 | 49 |
| Ā | MUT1 | C15T | 3 | 0 | 17 |
| Ā | MUT2 | A16G | 0 | 0 | 0 |
| Ā | MUT3A | T8C | 0 | 0 | 1 |
| Ā | MUT3B | T8A | 0 | 0 | 0 |