Spatial-temporal distribution of genotyped tuberculosis cases in a county with active transmission

Agarwal, Saroochi; Nguyen, Duc T.; Teeter, Larry D.; Graviss, Edward A.

doi:10.1186/s12879-017-2480-z

BMC Infectious Diseases

Table 2 Characteristics of Cases Found in the Large Clusters in Harris County, TX

From: Spatial-temporal distribution of genotyped tuberculosis cases in a county with active transmission

Variable	Total		G00010		G00014		G00769		G01521		G08964		P-value^a
Variable	N = 233	%	n = 118	50.64%	n = 38	16.31%	n = 33	14.16%	n = 26	11.16%	n = 18	7.73%
Age													0.057
0–4	5	2.2	3	2.5	1	2.6	0	0.0	0	0.0	1	5.6
5–15	2	0.9	0	0.0	0	0.0	1	3.0	0	0.0	1	5.6
15–24	22	9.4	5	4.2	3	7.9	7	21.2	2	7.7	5	27.8
25–44	64	27.5	35	29.7	9	23.7	8	24.2	7	26.9	5	27.8
45–64	109	46.8	61	51.7	18	47.4	12	36.4	14	53.9	4	22.2
65+	31	13.3	14	11.9	7	18.4	5	15.2	3	11.5	2	11.1
Gender													0.002
Female	60	25.8	22	18.6	10	26.3	16	48.5	4	15.4	8	44.4
Male	173	74.3	96	81.4	28	73.7	17	51.5	22	84.6	10	55.6
Ethnicity													<0.001
White	42	18.0	18	15.3	4	10.5	10	30.3	8	30.8	2	11.1
Black	112	48.1	73	61.9	13	34.2	16	48.5	7	26.9	3	16.7
Asian	9	3.9	6	5.1	1	2.6	1	3.0	0	0.0	1	5.6
Hispanic	69	29.6	21	17.8	20	52.6	5	15.2	11	42.3	12	66.7
Other	1	0.4	0	0.0	0	0.0	1	3.0	0	0.0	0	0.0
HIV status													0.252
Negative	176	75.5	86	72.9	27	71.1	28	84.8	22	84.6	13	72.2
Positive	35	15.0	23	19.5	7	18.4	2	6.1	2	7.7	1	5.6
Not Offered	22	9.4	9	7.6	4	10.5	3	9.1	2	7.7	4	22.2
Homeless													<0.001
No	195	83.7	87	73.7	35	92.1	33	100.0	22	84.6	18	100.0
Yes	38	16.3	31	26.3	3	7.9	0	0.0	4	15.4	0	0.0
Excessive Alcohol													0.002
No	125	53.7	67	56.8	17	44.7	21	63.6	6	23.1	14	77.8
Yes	108	46.4	51	43.2	21	55.3	12	36.4	20	76.9	4	22.2
Drug Use													0.047
No	166	71.2	80	67.8	25	65.8	29	87.9	16	61.5	16	88.9
Yes	67	28.8	38	32.2	13	34.2	4	12.1	10	38.5	2	11.1
Origin									0	0.0			0.004
U.S. Born	202	86.7	104	88.1	29	76.3	31	93.9	26	100.0	12	66.7
Foreign Born	31	13.3	14	11.9	9	23.7	2	6.1	0	0.0	6	33.3
Country of Origin													<0.001
United States	202	86.7	104	88.1	29	76.3	31	93.9	26	100.0	12	66.7
Mexico	18	7.7	8	6.8	5	13.2	0	0.0	0	0.0	5	27.8
Vietnam	5	2.2	4	3.4	0	0.0	0	0.0	0	0.0	1	5.6
Honduras	2	0.9	0	0.0	2	5.3	0	0.0	0	0.0	0	0.0
Other	6	2.6	2	1.7	2	5.3	2	6.1	0	0.0	0	0.0
Years in US median, (SD) [IQR]	18(13.2) [13,29]		22(15.1) [15,32]		17(9.3) [13, 17]		33.5(24.8) [16,51]		NA		18 (8.8) [12, 19]		0.490
Risk Factors
Diabetes	36	15.5	16	13.6	7	18.4	7	21.2	4	15.4	2	11.1	0.795
Contact of infectious TB Pt	19	8.2	9	7.6	2	5.3	5	15.2	1	3.9	2	11.1	0.481
Post-organ transplant	1	0.4	1	0.9	0	0.0	0	0.0	0	0.0	0	0.0	0.913
End stage renal dis.	3	1.3	3	2.5	0	0.0	0	0.0	0	0.0	0	0.0	0.564
Immunosuppression	4	1.7	2	1.7	1	2.6	13	0.0	0	0.0	0	0.0	0.862
Clinical Characteristics
Previous TB													0.706
No	219	94.0	110	93.2	35	92.1	32	97.0	24	92.3	18	100.0
Yes	14	6.0	8	6.8	3	7.9	1	3.0	2	7.7	0	0.0
SP smear													0.887
Negative	91	39.1	49	41.5	12	31.6	13	39.4	9	34.6	8	44.4
Positive	120	51.5	58	49.2	23	60.5	17	51.5	15	57.7	7	39.9
Not tested	22	9.4	11	9.3	3	7.9	3	9.1	2	7.7	3	16.7
SP Culture													0.708
Negative	18	7.7	11	9.3	1	2.6	2	6.1	1	3.9	3	16.7
Positive	193	82.8	94	79.7	34	89.5	28	84.9	23	88.5	14	77.8
Not tested	22	9.4	13	11.0	3	7.9	3	9.1	2	7.7	1	5.6
Chest X-Ray													0.518
Abnormal	213	91.4	104	88.1	35	92.1	31	93.9	25	96.2	18	100.0
Normal	9	3.9	8	6.8	1	2.6	0	0.0	0	0.0	0	0.0
Not tested	11	4.7	6	5.1	2	5.3	2	6.1	1	3.9	0	0.0
X-Ray Cavity													0.144
No	150	70.4	66	63.5	30	85.7	22	71.0	18	72.0	14	77.8
Yes	63	29.6	38	36.5	5	14.3	9	29.0	7	28.0	4	22.2
Pulmonary													0.569
No	13	5.6	8	6.8	1	2.6	3	9.1	1	3.9	0	0.0
Yes	220	94.4	110	93.2	37	97.4	30	90.9	25	96.2	18	100

Definition of abbreviations: SD Standard Deviation, IQR Interquartile Range
^aPearson’s chi-square test

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