Table 1 Demographic and clinical characteristics of HIV-1/TB co-infected patients according to vital status, INI-Fiocruz cohort, 2000–2010
Total | Alive | Dead | p value | |
|---|---|---|---|---|
Patients (n; %) | 310 (100) | 246 (79.4) | 64 (20.6) | |
Sex (n; %) | ||||
Male | 233 (75.2) | 185 (75.2) | 48 (75.0) | 1.000 |
Female | 77 (24.8) | 61 (24.8) | 16 (25.0) | |
Age at TB diagnosis (years) (median; IQR) | 36.9 (30.2–43.3) | 36.5 (30.1–42.5) | 37 (30.9–45.7) | 0.243 |
Race (n, %) | ||||
White | 111 (35.8) | 86 (35.0) | 25 (39.0) | |
Black | 79 (25.5) | 67 (27.2) | 12 (18.8) | 0.373 |
Mixed Black | 119 (38.4) | 92 (37.4) | 27 (42.2) | |
Unknown | 1 (0.3) | 1 (0.4) | - | |
Education (n; %) | ||||
Up to 4 years | 132 (42.6) | 102 (41,5) | 30 (46,9) | |
5–8 years | 86 (27.7) | 66 (26.8) | 20 (31.2) | 0.307 |
> 8 years | 92 (29.7) | 78 (31.7) | 14 (21.9) | |
CD4 T cell count at TB diagnosis (cells\mm3) (median; IQR) | 91 (42.0–215.0) | 96 (45.0–220.5) | 69.5 (34.0–146.0) | 0.079 |
HIV-1 RNA (log10 copies/ml) (median; IQR) | 5.2 (4.5–5.7) | 5.1 (4.5–5.7) | 5.4 (4.8–5.7) | 0.389 |
Interval between TB treatment and cART initiation (days) (Median; IQR) | 33 (17.5–61.0) | 35 (25.0–61.8) | 25.5 (0.8–57.0) | 0.018 |
Number of ARV changes due to toxicity (median; IQR) | 0 (0.0–0.0) | 0 (0.0–0.0) | 0 (0.0–0.8) | 0.574 |
PCP prophylaxis (n; %) | ||||
No | 14 (4.5) | 13 (5.3) | 1 (1.6) | 0.315 |
Yes | 196 (95.5) | 233 (94.7) | 63 (98.4) | |
IPT (n; %) | ||||
No | 270 (87) | |||
Yes | 4 (1) | |||
Unknown | 36 (12) | |||
Clinical presentation of TB (n; %) | ||||
Pulmonary | 47 (15.2) | 36 (14.6) | 11 (17.2) | |
Disseminated | 227 (73.2) | 179 (72.8) | 48 (75,0) | 0.573 |
Extrapulmonary, localized | 35 (11.3) | 30 (12.2) | 5 (7.8) | |
Unknown | 1 (0.3) | 1 (0.4) | - | |
TB treatment (n; %) | ||||
RHZ | 199 (64.2) | 160 (65.0) | 39 (60.8) | 0.643 |
RHZE | 105 (33.9) | 81 (32.9) | 24 (37.5) | 0.589 |
Others | 6 (1.9) | 5 (1.1) | 1 (1.7) | |
Rifampin discontinuation before the end of TB treatment (n; %) | 34 (11.2) | 24 (9.8) | 10 (15.6) | 0.471 |
Hospitalization during the first year after treatment TB (n; %) | ||||
No | 120 (38.7) | 107 (43.5) | 13 (20.3) | |
Yes | 190 (61.3) | 139 (56.5) | 51 (79.7) | 0.001 |
Mechanical ventilation (n; %) | 20 (6.4) | 6 (2.4) | 14 (21.8) | <0.001 |
MTB-IRIS (n, %) | 38 (12.3) | 29 (11.8) | 9 (14) | 0.763 |
Unknown | 3 (0.9) | 2 (0.8) | 1 (1.6) | |