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Table 1 Clinical features of 52 pediatric patients with disseminated cryptococcosisa

From: Clinical characteristics of disseminated cryptococcosis in previously healthy children in China

Clinical features Total
%(n/N)
CNS invasion
%(n/N)
Non-CNS invasion
%(n/N)
P
Age (year)     0.600
 < 3 21.2 (11/52) 22.2(8/36) 18.8(3/16)  
 3–5 42.3 (22/52) 38.9(14/36) 50.0(8/16)  
 ≥ 5 36.5 (19/52) 38.9(14/36) 31.3(5/16)  
Male 73.1 (38/52) 75.0(27/36) 68.8(11/16) 0.639
History of exposure to pigeon droppings 19.2 (10/52) 22.2(8/28) 12.5(2/14) 0.411
Main symptoms and signs
 Fever 100 (52/52) 100 (36/36) 100 (16/16) -
 Cough 53.8 (28/52) 55.6(20/36) 50.0(8/16) 0.710
 Hepatomegaly 51.9 (27/52) 47.2(17/36) 62.5(10/16) 0.308
 Meningeal irritation 34.6 (18/52) 100 (36/36) 0 0.000
 Headache 28.8 (15/52) 38.9(14/36) 6.3(1/16) 0.017
 Lymphadenopathy 27.0 (14/52) 33.3(12/36) 12.5(2/16) 0.118
 Splenomegaly 27.0 (14/52) 16.7(6/36) 50.0(8/16) 0.012
 Vomiting 23.1 (12/52) 30.6(11/36) 6.3(1/16) 0.056
 Abdominal pain 19.2 (10/52) 22.2(8/36) 12.5(2/16) 0.411
 Rash 11.5 (6/52) 13.9(5/36) 6.3(1/16) 0.426
 Lung auscultation 9.6 (5/52) 11.1(4/36) 6.3(1/16) 0.583
 Seizure 9.6 (5/52) 13.9(5/36) 0 0.117
 Jaundice 7.7 (4/52) 8.3(3/36) 6.3(1/16) 0.795
Invaded organs
 Lung 96.2 (50/52) 97.2(35/36) 93.8(15/16) 0.548
 CNS 69.2 (36/52) 100 (36/36) 0 0.000
 Abdomen lymph nodes 67.3 (35/52) 58.3(21/36) 87.5(14/16) 0.039
 Liver 63.5 (33/52) 63.9(23/36) 62.5(10/16) 0.924
 Spleen 50.0 (26/52) 47.2(17/36) 56.3(9/16) 0.548
 Peripheral lymph nodes 38.5 (20/52) 38.9(14/36) 37.5(6/16) 0.924
 Skin 11.5 (6/52) 13.9(5/36) 6.3(1/16) 0.426
Blood test
 Increased CRP 100 (52/52) 100 (36/36) 100 (16/16) -
 Increased ESR 100 (52/52) 100 (36/36) 100 (16/16) -
 Leukocytosis 92.3 (48/52) 91.7(33/36) 93.8(15/16) 0.795
 IgE 51.9 (27/52) 58.3(21/36) 37.5(6/16) 0.135
 Eosinophilia 42.3 (22/52) 36.1(13/36) 56.3(9/16) 0.175
 Abnormal liver function 38.5 (20/52) 38.9(14/36) 37.5(6/16) 0.924
Pathogen test
 Serum cryptococcal antigen 73.1 (38/52) 83.3(30/36) 50.0(8/16) 0.012
 Blood culture 46.2 (24/52) 58.3(21/36) 18.8(3/16) 0.008
 CSF cryptococcal antigen 42.9 (21/49) 58.3 (21/36) 0 0.000
 CSF ink staining 38.8 (19/49) 52.8 (19/36) 0 0.000
 CSF culture 32.4 (11/49) 30.6 (11/36) 0 0.013
Pathology 100 (19/19) 19.4(7/36) 75.0(12/16) 0.000
Chest radiographic abnormalities 90.4 (47/52) 88.9(32/36) 93.8(15/16) 0.583
Abdominal examination abnormalities 73.1 (38/52) 61.1(22/36) 100 (16/16) 0.004
Neurology imaging abnormalities 40.4 (21/52) 58.3(21/36) 0 0.000