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Table 2 Comparative analysis of the sub-samples’ characteristics

From: Antimicrobial consumption, costs and resistance patterns: a two year prospective study in a Romanian intensive care unit

Item

SI

SII

SIII

SIV

SI-II

p

SI-III

p

SI-IV

p

SII-III

p

SII-IV

p

SIII-IV

p

Average age [years(95% IC)](a)

58.23 (56.88-59.58)

62.90 (60.96–64.82)

61.32 (60.04–62.60)

60.10 (54.76–65.45)

<0.001

0.004

0.345

0.165

0.325

0.623

Male [n(%)](b)

432 (61.98)

191 (55.52)

368 (60.43)

21 (45.65)

0.045

0.565

0.027

0.139

0.206

0.049

Female [n (%)](b)

265 (38.02)

153 (44.47)

241 (39.57)

25 (54.35)

Average no. days of ICU stay [days(95% IC)] (c)

4.11 (3.83–4.40)

6.70 (6.05–7.34)

16.06 (14.68–17.43)

14.08 (10.69–17.47)

<0.001

<0.001

<0.001

<0.001

<0.001

0.926

Average no. days of antimicrobial drugs therapy [days(95% IC)] (c)

2.78 (2.62–2.93)

5.47 (4.96–5.96)

11.18 (10.28–12.06)

12.13 (9.31–14.95)

<0.001

<0.001

<0.001

<0.001

<0.001

0.232

Average no. days of empirical therapy [days(95% IC)] (c)

2.78 (2.62–2.93)

3,96 (3.65–4.27)

4.75 (4.48–5.01)

4,85 (3.89–5.81)

<0.001

<0.001

<0.001

0.035

0.132

0.915

Average no. days of definitive therapy [days(95% IC)]

/

6,25 (5.24–7.27)

11.46 (10.24–12.68)

11,53 (8.61–14.46)

/

/

/

0.005

0,001

0.449

Number of a antimicrobial drugs administered in the ICU [no.(95% IC)](b)

1.23 (1.19-1.27)

1.69 (1.58–1.60)

2.57 (2.42–2.72)

2.91 (2.36–3.47)

<0.001

<0.001

<0.001

<0.001

<0.001

0.114

Number of antimicrobial drugs administered in the ICU as empirical therapy [no.(95% IC)] (b)

1.23 (1.19–1.27)

1,24 (1.18–1.29)

1.40 (1.35–1.46)

1,36 (1.21–1.52)

0.754

<0.001

0.026

<0.001

0.055

0.846

Number of antimicrobial drugs administered in the ICU as definitive therapy [no.(95% IC)] (b)

/

1,84 (1.63–2.05)

2.45 (2.27–2.64)

2,93 (2.35–3.52)

/

/

/

0.004

<0.001

0.111

Deaths [n (%)] (b)

196 (28.12)

179 (52.03)

361 (59.27)

30 (65.21)

<0.001

<0.001

<0.001

0.030

0.092

0.428

Improved evolution [n (%)] (b)

475 (68.15)

155 (45.06)

211 (34.64)

16 (34.78)

<0.001

<0.001

<0.001

0.001

0.187

0.985

Stationary & aggravated evolution [n (%)] (b)

26 (3.73)

9 (2.62)

37 (6.08)

0 (0)

0.348

0.048

0.397

0.016

0.606

0.100

  1. (a)t-test was applied
  2. (b)chi-square test was applied
  3. (c)Mann-Whitney test was applied
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BMC Infectious Diseases

ISSN: 1471-2334

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