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Table 3 Characteristics of surgical and antimicrobial therapy

From: Clindamycin-rifampin combination therapy for staphylococcal periprosthetic joint infections: a retrospective observational study

 

Debridement and retention

n = 18

n

Revision

n = 18

n

Total

n = 36

n

Surgery

 Duration of surgery, minutes; median (range)

34 (18-94)

1 71 (90-290)

91 (18-290)

 Gentamicin beads used

9 (53)

-

 Bone impaction grafting

-

15 (83)

 Complete / partial revision

-

6 (33) / 12 (67)

Antimicrobial therapy

 Prior intravenous antibiotics

12

9

21

 Duration of iv therapy, days; median (range)

11 (2 - 56)

12 (2 - 15)

11 (2-56)

 Duration of iv + oral antibiotic therapy, days; med (range)

101 (31 – 239)

92 (80 – 139)

98 (31-239)

   < 90 days

3

2

5

  Hip PJIa, median (range)

98 (31-146)

92 (80-139)

95 (31-146)

  Knee PJI, median (range)

182 (117-239)

-

 

Rifampin dose reduction (300 mg twice daily)

3

3

6

Clindamycin-rifampin discontinuation

3

2

5

Due to:

 Comorbidities

2

1

3

Side effects

 Allergy/Rash

2

1

3

 Nausea

2

1

3

 Diarrhea

0

2

2

Treatment outcomes

 Failures

4

1

5

 Successfully treated

14 (78%)

17 (94%)

31 (86%)

 Patients completed clindamycin-rifampin regimen

15

16

31

  ➜ Successfully treated

14 (93%)

15 (94%)

29 (94%)

  1. aPJI, Periprosthetic Joint Infection