|
Cardiac disorders
|
50 (25.3)
|
177 (12.6)
|
−12.7; <0.00001
|
|
Coronary artery disorders
|
34 (17.2)
|
107 (7.6)
|
−9.6; <0.00001
|
|
Heart failures
|
15 (7.6)
|
39 (2.8)
|
−4.8; 0.00045
|
|
Endocrine disorders
|
17 (8.6)
|
57 (4.0)
|
−4.5; 0.00436
|
|
Hypothyroidism
|
14 (7.1)
|
41 (2.9)
|
−4.2; 0.00260
|
|
Eye disorders
|
14 (7.1)
|
33 (2.3)
|
−4.7; 0.00022
|
|
Diabetic retinopathy
|
9 (4.5)
|
0
|
−4.5; <0.00001
|
|
Hepatobiliary disorders
|
21 (10.6)
|
82 (5.8)
|
−4.8; 0.01014
|
|
Hepatic and hepatobiliary disorders
|
13 (6.6)
|
30 (2.1)
|
−4.4; 0.00030
|
|
Infections and infestations
|
55 (27.8)
|
228 (16.2)
|
−11.6; 0.00006
|
|
Urinary tract infections
|
35 (17.7)
|
119 (8.5)
|
−9.2; 0.00004
|
|
Viral infectious disorders
|
10 (5.1)
|
25 (1.8)
|
−3.3; 0.00313
|
|
Metabolism and nutrition disorders
|
198 (100.0)
|
166 (11.8)
|
−88.2; <0.00001
|
|
Glucose metabolism disorders, including diabetes
|
198 (100.0)
|
16 (1.1)
|
−98.9; <0.00001
|
|
Lipid metabolism disorders
|
31 (15.7)
|
62 (4.4)
|
−11.3; <0.00001
|
|
Obesity
|
13 (6.6)
|
37 (2.6)
|
−3.9; 0.00282
|
|
Musculoskeletal and connective tissue disorders
|
32 (16.2)
|
114 (8.1)
|
−8.1; 0.00022
|
|
Joint disorders
|
23 (11.6)
|
64 (4.5)
|
−7.1; 0.00004
|
|
Nervous system disorders
|
34 (17.2)
|
99 (7.0)
|
−10.1; <0.00001
|
|
Peripheral neuropathies
|
17 (8.6)
|
1 (0.1)
|
−8.5; <0.00001
|
|
Psychiatric disorders
|
22 (11.1)
|
79 (5.6)
|
−5.5; 0.00284
|
|
Depressive disorders
|
13 (6.6)
|
33 (2.3)
|
−4.2; 0.00086
|
|
Renal and urinary disorders
|
67 (33.8)
|
245 (17.4)
|
−16.4; <0.00001
|
|
Chronic kidney disease
|
17 (8.6)
|
19 (1.3)
|
−7.2; <0.00001
|
|
Diabetic nephropathy
|
12 (6.1)
|
0 (0.0)
|
−6.1; <0.00001
|
|
Urolithiases
|
22 (11.1)
|
81 (5.8)
|
−5.4; 0.00397
|
|
Respiratory, thoracic, and mediastinal disorders
|
28 (14.1)
|
87 (6.2)
|
−8.0; 0.00005
|
|
Bronchospasm and obstruction
|
17 (8.6)
|
49 (3.5)
|
−5.1; 0.0007
|
|
Vascular disorders
|
140 (70.7)
|
390 (27.7)
|
−43.0; <0.00001
|
|
Hypertension
|
131 (66.2)
|
342 (24.3)
|
−41.9; <0.00001
|
