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Table 3 Performance of direct sequencing in detecting of resistance of three antitubercular drugs

From: Early detection of multidrug- and pre-extensively drug-resistant tuberculosis from smear-positive sputum by direct sequencing

Drugs Gene targets No.(%) of strains/total no. of strains %
sensitivity
%
specificity
Phenotypically resistant Phenotypically resistant with mutations Phenotypically susceptible with mutations
rifampicin rpoB 65/186(34.95) 63/65(96.92) 2/121(1.65) 96.92 98.35
isoniazid katG, inhA promoter 61/186(32.80) 53/61(86.89) 1/125(0.80) 86.89 99.20
ofloxacin gyrA 40/186(21.51) 31/40(77.50) 4/146(2.74) 77.50 97.26