Table 3 Performance of direct sequencing in detecting of resistance of three antitubercular drugs
Drugs | Gene targets | No.(%) of strains/total no. of strains | % sensitivity | % specificity | ||
|---|---|---|---|---|---|---|
Phenotypically resistant | Phenotypically resistant with mutations | Phenotypically susceptible with mutations | ||||
rifampicin | rpoB | 65/186(34.95) | 63/65(96.92) | 2/121(1.65) | 96.92 | 98.35 |
isoniazid | katG, inhA promoter | 61/186(32.80) | 53/61(86.89) | 1/125(0.80) | 86.89 | 99.20 |
ofloxacin | gyrA | 40/186(21.51) | 31/40(77.50) | 4/146(2.74) | 77.50 | 97.26 |