Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?

Table 1 Frequency of Tregs in situ (lesions biopsy), ex vivo (peripheral blood), and in in vitro stimulated PBMC, and CTLA-4 expression by the Tregs, in the transplant recipient as compared with the T1R group

PB peripheral blood, PBMC peripheral blood mononuclear cells, Treg regulatory T-cells, ML Mycobacterium leprae antigen, PHA phytohemaglutinnin, T1R type 1 upgrading leprosy reaction
^aPercentage of FoxP3⁺CD127^low/− among CD4⁺CD25⁺ cells
^bPercentage of CTLA-4⁺ cells among Tregs
^cPatients with severe T1R without immunosuppressors (n = 14). Results presented as mean ± SEM

ISSN: 1471-2334