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Table 4 Association between IL-23R rs1884444 G/T and IL-23R rs7530511 C/T

From: Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

  SMA (Hb < 6.0 g/dL) SMA (Hb < 5.0 g/dL)
IL-23R haplotypes OR 95% CI P-value OR 95% CI P-value
 GC, (n = 342) 0.49 0.18–1.33 0.161 0.34 0.13–1.17 0.107
 GT, (n = 17) 1.04 0.33–3.31 0.949 1.92 0.52–7.06 0.328
 TC, (n = 67) 0.97 0.52–1.81 0.923 1.02 0.49–2.15 0.955
 TT, (n = 56) 1.12 1.07–4.19 0.030 2.50 1.19–5.29 0.016
  1. Haplotypes and SMA
  2. Children with P. falciparum malaria (n = 369) were grouped based on the modified definition of SMA (i.e., Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression model controlling for age, sex, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the regression analysis were non-carriers of the respective haplotypes
  3. Values in bold are significant p-values at a cut-off of p < 0.05