| |
SMA (Hb < 6.0 g/dL)
|
SMA (Hb < 5.0 g/dL)
|
|---|
|
IL-23R haplotypes
|
OR
|
95% CI
|
P-value
|
OR
|
95% CI
|
P-value
|
|---|
|
GC, (n = 342)
|
0.49
|
0.18–1.33
|
0.161
|
0.34
|
0.13–1.17
|
0.107
|
|
GT, (n = 17)
|
1.04
|
0.33–3.31
|
0.949
|
1.92
|
0.52–7.06
|
0.328
|
|
TC, (n = 67)
|
0.97
|
0.52–1.81
|
0.923
|
1.02
|
0.49–2.15
|
0.955
|
|
TT, (n = 56)
|
1.12
|
1.07–4.19
|
0.030
|
2.50
|
1.19–5.29
|
0.016
|
- Haplotypes and SMA
- Children with P. falciparum malaria (n = 369) were grouped based on the modified definition of SMA (i.e., Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression model controlling for age, sex, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the regression analysis were non-carriers of the respective haplotypes
- Values in bold are significant p-values at a cut-off of p < 0.05
