| |
SMA (Hb < 6.0 g/dL
|
SMA (Hb < 5.0 g/dL
|
|---|
|
Genotypes
|
OR
|
95% Cl
|
P value
|
OR
|
95% CI
|
P value
|
|---|
|
IL-23R rs1884444 G/T
|
IL-23R rs1884444 G/T
|
|
GG, (n = 253)
|
Ref
|
-
|
-
|
Ref
|
-
|
-
|
|
GT, (n = 100)
|
1.34
|
0.78–2.31
|
0.304
|
3.69
|
0.89–5.13
|
0.174
|
|
TT, (n = 16)
|
2.02
|
0.53–7.74
|
0.286
|
1.39
|
0.73–2.64
|
0.316
|
|
IL-23R rs7530511 C/T
|
IL-23R rs7530511 C/T
|
|
CC, (n = 303)
|
Ref
|
-
|
-
|
Ref
|
-
|
-
|
|
CT, (n = 54)
|
2.60
|
0.59–11.86
|
0.202
|
2.02
|
0.43–9.42
|
0.372
|
|
TT, (n = 12)
|
1.66
|
0.84–3.27
|
0.142
|
2.49
|
0.76–5.37
|
0.102
|
- Children (n = 369) with P. falciparum malaria were categorized on the basis of presence or absence of severe malarial anemia SMA (defined as Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression, controlling for age, sex, co-infections (HIV-1 status and bacteremia), sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the logistic regression analysis were the homozygous wild-type genotypes
