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Table 3 Association between IL-23R rs1884444 G/T and IL-23R rs7530511 C/T genotypes and SMA

From: Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

  SMA (Hb < 6.0 g/dL SMA (Hb < 5.0 g/dL
Genotypes OR 95% Cl P value OR 95% CI P value
IL-23R rs1884444 G/T IL-23R rs1884444 G/T
GG, (n = 253) Ref - - Ref - -
GT, (n = 100) 1.34 0.78–2.31 0.304 3.69 0.89–5.13 0.174
TT, (n = 16) 2.02 0.53–7.74 0.286 1.39 0.73–2.64 0.316
IL-23R rs7530511 C/T IL-23R rs7530511 C/T
CC, (n = 303) Ref - - Ref - -
CT, (n = 54) 2.60 0.59–11.86 0.202 2.02 0.43–9.42 0.372
TT, (n = 12) 1.66 0.84–3.27 0.142 2.49 0.76–5.37 0.102
  1. Children (n = 369) with P. falciparum malaria were categorized on the basis of presence or absence of severe malarial anemia SMA (defined as Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression, controlling for age, sex, co-infections (HIV-1 status and bacteremia), sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the logistic regression analysis were the homozygous wild-type genotypes