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Table 2 Distribution of IL-23R 1,884,444 G/T and IL-23R rs7530511 C/T genotypes in the clinical groups

From: Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

  N (%) with genotype in groupa
Genotypes Non-SMA
(Hb ≥ 6.0 g/dL)
(n = 207) 		SMA
(Hb < 6.0 g/dL)
(n = 162) 		P-value b
IL-23R rs1884444 G/T    
 GG, n (%) 146 (70.5) 107 (66.0)  
 GT, n (%) 55 (26.6) 45 (27.8) 0.278b
 TT, n (%) 6 (2.9) 10 (6.2)  
 X = 0.18    
IL-23R rs7530511 C/T    
 CC, n (%) 175 (84.5) 128 (79.0)  
 CT, n (%) 26 (12.6) 28 (17.3) 0.386b
 TT, n (%) 6 (2.9) 6 (3.7)  
 X = 0.11    
  1. aData are presented as n (%) of children. Children were grouped based on the modified definition of SMA (Hb < 6.0 g/dL, with any density parasitemia)
  2. bStatistical significance determined by the χ2 analysis. X: frequency of the variant allele
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BMC Infectious Diseases

ISSN: 1471-2334

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