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Table 3 Classification performance of different biomarkers and their optimum threshold by outcome determined using bootstrapping

From: Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

Predictor Outcome Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC
ALT ≥180 IU/L Unfavourable 75.0 (41.7-100) 97.3 (92.5-100) 85.7 (50.0-100) 95.6 (88.6-100) 0.864 (0.692-1.00)
Sodium <132 mmol/L Unfavourable 87.5 (57.1-100) 61.4 (46.5-76.1) 29.2 (11.1-48.3) 96.4 (88.9-100) 0.744 (0.583-0.869)
ALT <180 IU/L & sodium ≥125 mmol/L Favourable 81.8 (69.8-92.5) 100 (100-100) 100 (100-100) 50.0 (25.0-76.9) 0.909 (0.849-0.963)
  1. An unfavourable outcome was defined as the need for critical care intervention with mechanical ventilation, whereas a favourable outcome was defined as not requiring critical care intervention with mechanical ventilation. 95% confidence intervals determined by bootstrapping (1000 replicates) are in parentheses for each parameter. Abbreviations: ALT alanine aminotransferase, AUC area under the receiver operator curve (equivalent to the balanced accuracy), PPV positive predictive value, NPV negative predictive value