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Table 1 Baseline characteristics, co-morbidities, admission blood tests, neurological tests and outcomes of a UK cohort of patients with miliary tuberculosis

From: Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

Variable n (%) or median (range)
Age (years) 41 (10-87)
Sex
 Male 31 (60%)
Ethnic Origin
 Asian 32 (62%)
 Black-African 11 (21%)
 White 5 (10%)
 Other 4 (8%)
Previous diagnosis of TB 2 (4%)
Co-morbidities
 None 33 (63%)
 Diabetes 6 (12%)
 CKD 4 (8%)
 Anti-TNF therapy 3 (6%)
 Alcoholism 3 (6%)
 Heart failure 2 (4%)
 HIV positive 3/49 (6%)
 Hepatitis B sAg positive 3/49 (6%)
 Hepatitis C positive 1/47 (2%)
 Vitamin D deficient 44/57 (94%)
Admission blood tests  
 Sodium (mmol/L) 132 (106-141)
 Creatinine (mmol/L) 68 (44-559)
 Alanine aminotransferase (IU/L) 46 (5-453)
 Alkaline phosphatase (iU/L) 121 (39-866)
 Bilirubin (μmol/L) 12 (4-39)
 Erythrocyte sedimentation rate (mm/h) 33 (1-127)
 C-reactive protein (mg/L) 56 (3-433)
 White cell count (×109/L) 7.1 (1.1-17.0)
 Neutrophil count (×109/L) 5.3 (0.9-15.7)
 Platelet count (×109/L) 238 (53-574)
 Ferritin (μg/L) 522 (10-19,070)
 Vitamin D (nmol/L) 16 (2-117)
Assessment for CNS involvement
 Number of patients assessed for CNS infection 29 (56%)
 - CT head consistent with CNS infection 6/19 (32%)
 - MRI brain consistent with CNS infection 10/11 (91%)
 - Lumbar puncture consistent with CNS infection 4/17 (24%)
 Total number with confirmed CNS infection 15 (29%)
Outcomes and adverse events
 Death (by one-year) 1 (2%)
 Mechanical ventilation 8 (15%)
 Drug-induced hepatitis 7 (13%)
 Seizure 4 (8%)
 Pneumothorax 3 (6%)
 Haemophagocytic lymphohistiocytosis 2 (4%)
 Pericardial effusion 2 (4%)
  1. Data are presented as n (%), except for age and blood tests results which are presented as median (range)
  2. Abbreviations: TB Tuberculosis, CKD chronic kidney disease, TNF tumour necrosis factor, HIV human immunodeficiency virus, CNS central nervous system, CT computer tomography; MRI: magnetic resonance imaging, sAG surface antigen