From: Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort
Variable | n (%) or median (range) |
---|---|
Age (years) | 41 (10-87) |
Sex | |
Male | 31 (60%) |
Ethnic Origin | |
Asian | 32 (62%) |
Black-African | 11 (21%) |
White | 5 (10%) |
Other | 4 (8%) |
Previous diagnosis of TB | 2 (4%) |
Co-morbidities | |
None | 33 (63%) |
Diabetes | 6 (12%) |
CKD | 4 (8%) |
Anti-TNF therapy | 3 (6%) |
Alcoholism | 3 (6%) |
Heart failure | 2 (4%) |
HIV positive | 3/49 (6%) |
Hepatitis B sAg positive | 3/49 (6%) |
Hepatitis C positive | 1/47 (2%) |
Vitamin D deficient | 44/57 (94%) |
Admission blood tests | |
Sodium (mmol/L) | 132 (106-141) |
Creatinine (mmol/L) | 68 (44-559) |
Alanine aminotransferase (IU/L) | 46 (5-453) |
Alkaline phosphatase (iU/L) | 121 (39-866) |
Bilirubin (μmol/L) | 12 (4-39) |
Erythrocyte sedimentation rate (mm/h) | 33 (1-127) |
C-reactive protein (mg/L) | 56 (3-433) |
White cell count (×109/L) | 7.1 (1.1-17.0) |
Neutrophil count (×109/L) | 5.3 (0.9-15.7) |
Platelet count (×109/L) | 238 (53-574) |
Ferritin (μg/L) | 522 (10-19,070) |
Vitamin D (nmol/L) | 16 (2-117) |
Assessment for CNS involvement | |
Number of patients assessed for CNS infection | 29 (56%) |
- CT head consistent with CNS infection | 6/19 (32%) |
- MRI brain consistent with CNS infection | 10/11 (91%) |
- Lumbar puncture consistent with CNS infection | 4/17 (24%) |
Total number with confirmed CNS infection | 15 (29%) |
Outcomes and adverse events | |
Death (by one-year) | 1 (2%) |
Mechanical ventilation | 8 (15%) |
Drug-induced hepatitis | 7 (13%) |
Seizure | 4 (8%) |
Pneumothorax | 3 (6%) |
Haemophagocytic lymphohistiocytosis | 2 (4%) |
Pericardial effusion | 2 (4%) |