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Table 1 Baseline characteristics, co-morbidities, admission blood tests, neurological tests and outcomes of a UK cohort of patients with miliary tuberculosis

From: Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

Variable

n (%) or median (range)

Age (years)

41 (10-87)

Sex

 Male

31 (60%)

Ethnic Origin

 Asian

32 (62%)

 Black-African

11 (21%)

 White

5 (10%)

 Other

4 (8%)

Previous diagnosis of TB

2 (4%)

Co-morbidities

 None

33 (63%)

 Diabetes

6 (12%)

 CKD

4 (8%)

 Anti-TNF therapy

3 (6%)

 Alcoholism

3 (6%)

 Heart failure

2 (4%)

 HIV positive

3/49 (6%)

 Hepatitis B sAg positive

3/49 (6%)

 Hepatitis C positive

1/47 (2%)

 Vitamin D deficient

44/57 (94%)

Admission blood tests

 

 Sodium (mmol/L)

132 (106-141)

 Creatinine (mmol/L)

68 (44-559)

 Alanine aminotransferase (IU/L)

46 (5-453)

 Alkaline phosphatase (iU/L)

121 (39-866)

 Bilirubin (μmol/L)

12 (4-39)

 Erythrocyte sedimentation rate (mm/h)

33 (1-127)

 C-reactive protein (mg/L)

56 (3-433)

 White cell count (×109/L)

7.1 (1.1-17.0)

 Neutrophil count (×109/L)

5.3 (0.9-15.7)

 Platelet count (×109/L)

238 (53-574)

 Ferritin (μg/L)

522 (10-19,070)

 Vitamin D (nmol/L)

16 (2-117)

Assessment for CNS involvement

 Number of patients assessed for CNS infection

29 (56%)

 - CT head consistent with CNS infection

6/19 (32%)

 - MRI brain consistent with CNS infection

10/11 (91%)

 - Lumbar puncture consistent with CNS infection

4/17 (24%)

 Total number with confirmed CNS infection

15 (29%)

Outcomes and adverse events

 Death (by one-year)

1 (2%)

 Mechanical ventilation

8 (15%)

 Drug-induced hepatitis

7 (13%)

 Seizure

4 (8%)

 Pneumothorax

3 (6%)

 Haemophagocytic lymphohistiocytosis

2 (4%)

 Pericardial effusion

2 (4%)

  1. Data are presented as n (%), except for age and blood tests results which are presented as median (range)
  2. Abbreviations: TB Tuberculosis, CKD chronic kidney disease, TNF tumour necrosis factor, HIV human immunodeficiency virus, CNS central nervous system, CT computer tomography; MRI: magnetic resonance imaging, sAG surface antigen