Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

Table 2 Table of included paediatric studies

Study	Design	Age	Setting	n	Prevalence of sepsis	Procalcitonin lab assay	Timing of test	PCT Cut-off(ng/ml)	Inclusion Criteria	Outcome Diagnosis	Sensitivity %	Specificity %	AUC ROC
Calò Carducci 2014 [49]	Prospective	2 months	Hospital Ward	64	64	PCT-LIA	0 h	0.55	SIRS	MC or CR	88	74	-
Groselj-Grenc 2009 [35]	Prospective	1 month-12 years	PICU	36	67	PCT-LIA	0 h	0.28	SIRS	CR	83	75	0.83
Groselj-Grenc 2009 [35]	Prospective	1 month-12 years	PICU	36	67	PCT-LIA	24 h	0.65	SIRS	CR	81	88	0.86
Pourakbari 2010 [51]	Prospective	42.8 +/− 3,5 months	Hospital ward + Emergency Dept	158	79	PCT-Q	0 h	0.5	SIRS	MC	65	47	-
								2			44	80	-
								10			30	89	-
Simon 2008 [50]	Prospective	80 months +/− 71	PICU	64	39	PCT-LIA	24 h	0.5	SIRS	CR	82	36	0.71
								2.5			68	74
								5			50	82

AUC Area Under the Curve, CR Chart Review, MC Microbiologically Confirmed, NICU Neonatal Intensive-Care Unit, PCT Procalcitonin, PCT LIA Procalcitonin Manual Assay, PCT-Q Procalcitonin Rapid Assay, ROC Receiver Operating Characteristic, SIRS Systemic Inflammatory Response Syndrome

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