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Table 2 Table of included paediatric studies

From: Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

Study Design Age Setting n Prevalence of sepsis Procalcitonin lab assay Timing of test PCT Cut-off(ng/ml) Inclusion Criteria Outcome Diagnosis Sensitivity % Specificity % AUC ROC
Calò Carducci 2014 [49] Prospective 2 months Hospital Ward 64 64 PCT-LIA 0 h 0.55 SIRS MC or CR 88 74 -
Groselj-Grenc 2009 [35] Prospective 1 month-12 years PICU 36 67 PCT-LIA 0 h 0.28 SIRS CR 83 75 0.83
24 h 0.65 81 88 0.86
Pourakbari 2010 [51] Prospective 42.8 +/− 3,5 months Hospital ward + Emergency Dept 158 79 PCT-Q 0 h 0.5 SIRS MC 65 47 -
2 44 80 -
10 30 89 -
Simon 2008 [50] Prospective 80 months +/− 71 PICU 64 39 PCT-LIA 24 h 0.5 SIRS CR 82 36 0.71
2.5 68 74
5 50 82
  1. AUC Area Under the Curve, CR Chart Review, MC Microbiologically Confirmed, NICU Neonatal Intensive-Care Unit, PCT Procalcitonin, PCT LIA Procalcitonin Manual Assay, PCT-Q Procalcitonin Rapid Assay, ROC Receiver Operating Characteristic, SIRS Systemic Inflammatory Response Syndrome