Study | Design | Age | Early or Late Onset | Setting | n | Prevalence of sepsis (%) | Procalcitonin lab assay | Timing of test | PCT Cut-off (ng/ml) | Inclusion Criteria | Sepsis Diagnosis | Sensitivity | Specificity | AUC ROC |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adib 2012 [36] | Cross-sectional | 0 to 28 days | Early and Late | NICU | 69 | 29 | PCT-LIA | 0 h | 1.15 | Suspected sepsis | MC | 70 | 40 | - |
Bender 2008 [37] | Prospective | 0-72 h | Early | NICU | 123 | 24 | PCT-LIA | 0 h | 5.75 | Suspected sepsis | MC or CR | 68 | 67 | - |
25 | 21 | 92 | - | |||||||||||
Bonac 2000 [38] | Prospective | 2.5 days | Early | NICU | 58 | 15 | PCT-LIA | 0 h | 9,98 | Suspected sepsis | MC or CR | 59 | 82 | 0.61 |
24 h | 13.03 | 50 | 100 | 0.73 | ||||||||||
48 h | 3.07 | 52 | 91 | - | ||||||||||
Boo 2008 [39] | Prospective | Preterm- 54 days | Early and Late | NICU | 87 | 21 | Semi-quantitative PCT-Q | 0 h | 0,5 | Suspected Sepsis | MC | 89 | 41 | - |
12-24 h | 2 | 89 | 65 | - | ||||||||||
36-48 h | 10 | 72 | 75 | - | ||||||||||
Groselj-Grenc 2009 [35] | Prospective | 1-18 days | Early and Late | NICU | 46 | 63 | PCT-LIA | 0 h | 2.28 | SIRS | MC or CR | 82 | 48 | 0.67 |
24 h | 5.55 | 31 | 100 | 0.64 | ||||||||||
Guibourdenche 2002 [40] | Prospective | 1 day | Early | NICU | 120 | 18 | PCT-LIA | 0-72 h | 2.5 | Suspected sepsis | MC or CR | 87 | 90 | - |
Koskenvuo 2003 [41] | Prospective | 0-72 h | Early | Medical | 22 | 22 | PCT-LIA | 12 h | 2 | SIRS | MC or CR | 86.4 | 47.2 | - |
Lopez Sastre 2006 [42] | Prospective | 4 - 28 days of life | Late | NICU | 100 | 61 | PCT-LIA | 0 h | 0.59 | Suspected sepsis | MC | 82 | 81 | 0.78 |
12-24 h | 1.34 | 74 | 81 | 0.81 | ||||||||||
36-48 h | 0.69 | 87 | 73 | 0.80 | ||||||||||
Naher 2011 [43] | Cross sectional | 37wks gestational age | Early and Late | NICU | 50 | 80 | Semi-quantitative PCT-Q | 0 h | 0.5 | Suspected Sepsis | MC or CR | 70 | 90 | 0.77 |
Resch 2003 [44] | Prospective | 35.5 weeks Gestational age | Early | NICU | 68 | 61 | PCT-LIA | 0 h | 2 | Suspected Sepsis | MC or CR | 83 | 61 | - |
6 | 77 | 91 | - | |||||||||||
14 | 63 | 100 | - | |||||||||||
Sakha 2008 [45] | Cross-sectional | 0 to 28 days | Early and Late | Neonatal Ward | 117 | 23 | PCT-LIA | - | 2.5 | Suspected sepsis | MC | 67 | 50 | 0.61 |
Schlapbach 2013 [46] | Prospective | 0-72 h of life, gestational age > 34 weeks | Early | NICU | 137 | 24.1 | PCT-LIA | 0 h | 2 | Suspected sepsis | MC or CR | 87,9 | 51 | - |
Vazzalwar 2005 [47] | Prospective | ≥ 7 days | Late | NICU | 51 | 35.3 | PCT-LIA | 0 h | 0.5 | Suspected sepsis | MC or CR | 94.4 | 36.4 | - |
1 | 77.8 | 63.6 | - | |||||||||||
Zahedpasha 2009 [48] | Prospective | 0 to 28 days | Early and Late | NICU | 38 | 28.9 | PCT-LIA | 0 h | 0,5 | Suspected sepsis | MC or CR | 100 | 25.9 | - |
2 | 100 | 33.3 | - | |||||||||||
10 | 90.9 | 85.2 | - |