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Table 1 Table of included neonatal studies

From: Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

Study Design Age Early or Late Onset Setting n Prevalence of sepsis (%) Procalcitonin lab assay Timing of test PCT
Cut-off (ng/ml)
Inclusion Criteria Sepsis Diagnosis Sensitivity Specificity AUC ROC
Adib 2012 [36] Cross-sectional 0 to 28 days Early and Late NICU 69 29 PCT-LIA 0 h 1.15 Suspected sepsis MC 70 40 -
Bender 2008 [37] Prospective 0-72 h Early NICU 123 24 PCT-LIA 0 h 5.75 Suspected sepsis MC or CR 68 67 -
25 21 92 -
Bonac 2000 [38] Prospective 2.5 days Early NICU 58 15 PCT-LIA 0 h 9,98 Suspected sepsis MC or CR 59 82 0.61
24 h 13.03 50 100 0.73
48 h 3.07 52 91 -
Boo 2008 [39] Prospective Preterm-
54 days
Early and Late NICU 87 21 Semi-quantitative
PCT-Q
0 h 0,5 Suspected Sepsis MC 89 41 -
12-24 h 2 89 65 -
36-48 h 10 72 75 -
Groselj-Grenc 2009 [35] Prospective 1-18 days Early and Late NICU 46 63 PCT-LIA 0 h 2.28 SIRS MC or CR 82 48 0.67
24 h 5.55 31 100 0.64
Guibourdenche 2002 [40] Prospective 1 day Early NICU 120 18 PCT-LIA 0-72 h 2.5 Suspected sepsis MC or CR 87 90 -
Koskenvuo 2003 [41] Prospective 0-72 h Early Medical 22 22 PCT-LIA 12 h 2 SIRS MC or CR 86.4 47.2 -
Lopez Sastre 2006 [42] Prospective 4 - 28 days of life Late NICU 100 61 PCT-LIA 0 h 0.59 Suspected sepsis MC 82 81 0.78
12-24 h 1.34 74 81 0.81
36-48 h 0.69 87 73 0.80
Naher 2011 [43] Cross sectional 37wks gestational age Early and Late NICU 50 80 Semi-quantitative
PCT-Q
0 h 0.5 Suspected Sepsis MC or CR 70 90 0.77
Resch 2003 [44] Prospective 35.5 weeks Gestational age Early NICU 68 61 PCT-LIA 0 h 2 Suspected Sepsis MC or CR 83 61 -
6 77 91 -
14 63 100 -
Sakha 2008 [45] Cross-sectional 0 to 28 days Early and Late Neonatal Ward 117 23 PCT-LIA - 2.5 Suspected sepsis MC 67 50 0.61
Schlapbach 2013 [46] Prospective 0-72 h of life, gestational age > 34 weeks Early NICU 137 24.1 PCT-LIA 0 h 2 Suspected sepsis MC or CR 87,9 51 -
Vazzalwar 2005 [47] Prospective ≥ 7 days Late NICU 51 35.3 PCT-LIA 0 h 0.5 Suspected sepsis MC or CR 94.4 36.4 -
1 77.8 63.6 -
Zahedpasha 2009 [48] Prospective 0 to 28 days Early and Late NICU 38 28.9 PCT-LIA 0 h 0,5 Suspected sepsis MC or CR 100 25.9 -
2 100 33.3 -
10 90.9 85.2 -
  1. AUC Area Under the Curve, CR Chart Review, MC Microbiologically Confirmed, NICU Neonatal Intensive-Care Unit, PCT Procalcitonin, PCT LIA Procalcitonin Manual Assay, PCT-Q Procalcitonin Rapid Assay, ROC Receiver Operating Characteristic, SIRS Systemic Inflammatory Response Syndrome