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Table 1 Table of included neonatal studies

From: Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

Study

Design

Age

Early or Late Onset

Setting

n

Prevalence of sepsis (%)

Procalcitonin lab assay

Timing of test

PCT

Cut-off (ng/ml)

Inclusion Criteria

Sepsis Diagnosis

Sensitivity

Specificity

AUC ROC

Adib 2012 [36]

Cross-sectional

0 to 28 days

Early and Late

NICU

69

29

PCT-LIA

0 h

1.15

Suspected sepsis

MC

70

40

-

Bender 2008 [37]

Prospective

0-72 h

Early

NICU

123

24

PCT-LIA

0 h

5.75

Suspected sepsis

MC or CR

68

67

-

25

21

92

-

Bonac 2000 [38]

Prospective

2.5 days

Early

NICU

58

15

PCT-LIA

0 h

9,98

Suspected sepsis

MC or CR

59

82

0.61

24 h

13.03

50

100

0.73

48 h

3.07

52

91

-

Boo 2008 [39]

Prospective

Preterm-

54 days

Early and Late

NICU

87

21

Semi-quantitative

PCT-Q

0 h

0,5

Suspected Sepsis

MC

89

41

-

12-24 h

2

89

65

-

36-48 h

10

72

75

-

Groselj-Grenc 2009 [35]

Prospective

1-18 days

Early and Late

NICU

46

63

PCT-LIA

0 h

2.28

SIRS

MC or CR

82

48

0.67

24 h

5.55

31

100

0.64

Guibourdenche 2002 [40]

Prospective

1 day

Early

NICU

120

18

PCT-LIA

0-72 h

2.5

Suspected sepsis

MC or CR

87

90

-

Koskenvuo 2003 [41]

Prospective

0-72 h

Early

Medical

22

22

PCT-LIA

12 h

2

SIRS

MC or CR

86.4

47.2

-

Lopez Sastre 2006 [42]

Prospective

4 - 28 days of life

Late

NICU

100

61

PCT-LIA

0 h

0.59

Suspected sepsis

MC

82

81

0.78

12-24 h

1.34

74

81

0.81

36-48 h

0.69

87

73

0.80

Naher 2011 [43]

Cross sectional

37wks gestational age

Early and Late

NICU

50

80

Semi-quantitative

PCT-Q

0 h

0.5

Suspected Sepsis

MC or CR

70

90

0.77

Resch 2003 [44]

Prospective

35.5 weeks Gestational age

Early

NICU

68

61

PCT-LIA

0 h

2

Suspected Sepsis

MC or CR

83

61

-

6

77

91

-

14

63

100

-

Sakha 2008 [45]

Cross-sectional

0 to 28 days

Early and Late

Neonatal Ward

117

23

PCT-LIA

-

2.5

Suspected sepsis

MC

67

50

0.61

Schlapbach 2013 [46]

Prospective

0-72 h of life, gestational age > 34 weeks

Early

NICU

137

24.1

PCT-LIA

0 h

2

Suspected sepsis

MC or CR

87,9

51

-

Vazzalwar 2005 [47]

Prospective

≥ 7 days

Late

NICU

51

35.3

PCT-LIA

0 h

0.5

Suspected sepsis

MC or CR

94.4

36.4

-

1

77.8

63.6

-

Zahedpasha 2009 [48]

Prospective

0 to 28 days

Early and Late

NICU

38

28.9

PCT-LIA

0 h

0,5

Suspected sepsis

MC or CR

100

25.9

-

2

100

33.3

-

10

90.9

85.2

-

  1. AUC Area Under the Curve, CR Chart Review, MC Microbiologically Confirmed, NICU Neonatal Intensive-Care Unit, PCT Procalcitonin, PCT LIA Procalcitonin Manual Assay, PCT-Q Procalcitonin Rapid Assay, ROC Receiver Operating Characteristic, SIRS Systemic Inflammatory Response Syndrome