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Table 4 FcγRIIA-131/FcγRIIIA-176/FcγRIIIB haplotypes distribution within the study groups and association with severe malarial anemia

From: Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

FcγRIIA-131His/Arg, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 haplotypes Study groups P-value* SMA (Hb < 6.0 g/dL
SMA
n (%)
non-SMA
n (%)
OR 95% CI P-value**
131Arg/176F/NA2 (n = 171) 79 (69.3) 92 (57.5) 0.044 1.70 1.02–2.93 0.036
131His/176F/NA1 (n = 59) 30 (26.3) 29 (18.1) 0.104 1.80 0.98–3.30 0.057
131His/176F/NA2 (n = 87) 32 (28.1) 55 (34.4) 0.269 0.76 0.44–1.32 0.334
131His/176 V/NA1 (n = 79) 28 (24.6) 51 (31.9) 0.188 0.71 0.41–1.25 0.234
  1. Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), alpha-thalassemia and G6PD deficiency. The reference groups in the regression analysis were the non-carriage of respective haplotypic structures. n; the number of participants with the respective haplotype. n (%); number (percentage) of participants with respective haplotype in each study group. *P-value determined using Chi-square (χ2). **P-values determined using logistics regression analysis. All P-values were considered statistically significant at P ≤ 0.05
  2. Values in bold are significant p-values at a cut-off of p≤0.05