|
FcγRIIA-131His/Arg, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 haplotypes
|
Study groups
|
P-value*
|
SMA (Hb < 6.0 g/dL
|
|---|
SMA
n (%)
|
non-SMA
n (%)
|
OR
|
95% CI
|
P-value**
|
|---|
|
131Arg/176F/NA2 (n = 171)
|
79 (69.3)
|
92 (57.5)
|
0.044
|
1.70
|
1.02–2.93
|
0.036
|
|
131His/176F/NA1 (n = 59)
|
30 (26.3)
|
29 (18.1)
|
0.104
|
1.80
|
0.98–3.30
|
0.057
|
|
131His/176F/NA2 (n = 87)
|
32 (28.1)
|
55 (34.4)
|
0.269
|
0.76
|
0.44–1.32
|
0.334
|
|
131His/176 V/NA1 (n = 79)
|
28 (24.6)
|
51 (31.9)
|
0.188
|
0.71
|
0.41–1.25
|
0.234
|
- Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), alpha-thalassemia and G6PD deficiency. The reference groups in the regression analysis were the non-carriage of respective haplotypic structures. n; the number of participants with the respective haplotype. n (%); number (percentage) of participants with respective haplotype in each study group. *P-value determined using Chi-square (χ2). **P-values determined using logistics regression analysis. All P-values were considered statistically significant at P ≤ 0.05
- Values in bold are significant p-values at a cut-off of p≤0.05
