Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

Table 4 FcγRIIA-131/FcγRIIIA-176/FcγRIIIB haplotypes distribution within the study groups and association with severe malarial anemia

FcγRIIA-131His/Arg, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 haplotypes	Study groups		P-value*	SMA (Hb < 6.0 g/dL
	SMA n (%)	non-SMA n (%)	P-value*	OR	95% CI	P-value**
131Arg/176F/NA2 (n = 171)	79 (69.3)	92 (57.5)	0.044	1.70	1.02–2.93	0.036
131His/176F/NA1 (n = 59)	30 (26.3)	29 (18.1)	0.104	1.80	0.98–3.30	0.057
131His/176F/NA2 (n = 87)	32 (28.1)	55 (34.4)	0.269	0.76	0.44–1.32	0.334
131His/176 V/NA1 (n = 79)	28 (24.6)	51 (31.9)	0.188	0.71	0.41–1.25	0.234

Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), alpha-thalassemia and G6PD deficiency. The reference groups in the regression analysis were the non-carriage of respective haplotypic structures. n; the number of participants with the respective haplotype. n (%); number (percentage) of participants with respective haplotype in each study group. *P-value determined using Chi-square (χ²). **P-values determined using logistics regression analysis. All P-values were considered statistically significant at P ≤ 0.05
Values in bold are significant p-values at a cut-off of p≤0.05

ISSN: 1471-2334