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Table 3 Association between FcγRIIA-131Arg/His, FcγRIIIA-176F/V, FcγRIIIB-NA1/NA2 and severe malarial anemia (SMA, Hb < 6.0 g/dL)

From: Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

FcγR genotype models    SMA (Hb < 6.0 g/dL)
SMA Non-SMA OR 95% CI P-value
FcγRIIA-131Arg/His
 Dominant, (His/His, n = 75) 25 50 0.59 0.33–1.05 0.077
 Additive, (Arg/His, n = 130) 59 71 1.52 0.72–2.93 0.298
 Recessive, (Arg/Arg, n = 69) 30 39 0.98 0.56–1.75 0.963
FcγRIIIA-176 F/V
 Dominant, (F/F, n = 138) 61 77 1.27 0.79–2.10 0.343
 Additive, (F/V, n = 105) 45 60 0.77 0.63–1.83 0.796
 Recessive, (V/V, n = 31) 8 23 0.43 0.18–1.02 0.056
FcγRIIIB-NA1/NA2
 Dominant, (NA2/NA2, n = 93) 35 58 0.76 0.44–1.28 0.786
 Additive, (NA1/NA2, n = 167) 73 94 1.34 0.78–2.30 0.288
 Recessive, (NA1/NA1, n = 14) 6 8 1.20 0.36–3.94 0.767
  1. Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS) and G6PD deficiency. The reference groups in the logistic regression analysis were the absence of the respective models for each genotype. n = the number of participants with the respective genotype. P-values were considered significant at P ≤ 0.05
  2. Values in bold are significant p-values at a cut-off of p≤0.05