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Table 3 Association between FcγRIIA-131Arg/His, FcγRIIIA-176F/V, FcγRIIIB-NA1/NA2 and severe malarial anemia (SMA, Hb < 6.0 g/dL)

From: Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

FcγR genotype models

  

SMA (Hb < 6.0 g/dL)

SMA

Non-SMA

OR

95% CI

P-value

FcγRIIA-131Arg/His

 Dominant, (His/His, n = 75)

25

50

0.59

0.33–1.05

0.077

 Additive, (Arg/His, n = 130)

59

71

1.52

0.72–2.93

0.298

 Recessive, (Arg/Arg, n = 69)

30

39

0.98

0.56–1.75

0.963

FcγRIIIA-176 F/V

 Dominant, (F/F, n = 138)

61

77

1.27

0.79–2.10

0.343

 Additive, (F/V, n = 105)

45

60

0.77

0.63–1.83

0.796

 Recessive, (V/V, n = 31)

8

23

0.43

0.18–1.02

0.056

FcγRIIIB-NA1/NA2

 Dominant, (NA2/NA2, n = 93)

35

58

0.76

0.44–1.28

0.786

 Additive, (NA1/NA2, n = 167)

73

94

1.34

0.78–2.30

0.288

 Recessive, (NA1/NA1, n = 14)

6

8

1.20

0.36–3.94

0.767

  1. Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS) and G6PD deficiency. The reference groups in the logistic regression analysis were the absence of the respective models for each genotype. n = the number of participants with the respective genotype. P-values were considered significant at P ≤ 0.05
  2. Values in bold are significant p-values at a cut-off of p≤0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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