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Table 2 Distribution of FcγRIIA-131Arg/His, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 genotypes within the study groups

From: Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

 

N (%) with genotype in groupa

HWE, P-value

(SMA + non-SMA) c

Genotypes

SMA

(Hb < 6.0 g/dL)

(n = 114)

Non-SMA

(Hb ≥ 6.0 g/dL)

(n = 160)

P-value b

FcγRIIA-131Arg/His

 Arg/Arg, n (%)

30 (26.3)

39 (24.3)

  

 Arg/His n (%)

59 (51.8)

71 (44.4)

0.226b

0.402b

 His/His, n (%)

25 (21.9)

50 (31.3)

 

 X(His) = 0.48

    

FcγRIIIA-176 F/V

 FF, n (%)

61 (53.5)

77 (48.1)

  

 FV, n (%)

45 (39.5)

60 (37.5)

0.162b

0.113b

 VV, n (%)

8 (7.0)

23 (14.4)

  

 X(V) = 0.30

    

FcγRIIIB-NA1/NA2

 NA1/NA1

6 (5.3)

8 (5.0)

  

 NA1/NA2

73 (64.0)

94 (58.8)

0.632b

<0.001 b

 NA2/NA2

35 (30.7)

58 (36.2)

  

 X(NA1) = 0.36

    
  1. aData are presented as n (%) of children. Children with parasitemia were categorized on the basis of presence or absence of severe malarial anemia SMA based (defined as Hb < 6.0 g/dL, with any density parasitemia). bStatistical significance determined by χ2 analysis. X; the overall minor allele frequency in the study population. c HWE Hardy-Weinberg Equilibrium
  2. Values in bold are significant p-values at a cut-off of p≤0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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