Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

Table 1 Demographic clinical and laboratory characteristics of study participants

Characteristics	Clinical groups
	SMA	non-SMA	P-value
	(Hb < 6.0 g/dL)	(Hb ≥ 6.0 g/dL)	P-value
	n = 114	n = 160
Sex, n (%)
Male	49 (43.00)	89 (55.40)	0.039 ^a
Female	65 (57.00)	71 (44.60)	0.039 ^a
Age, (months)	8.0 (7.00)	13.5 (8.80)	<0.001 ^b
Log₁₀ of parasitemia	4.09 (±0.07)	4.24 (±0.06)	0.088^c
HDP (≥10, 000 parasites/μL)	71/114 (62.3)	115/160 (71.9)	0.094^a
Temperature, (°C)	38.0 (1.20)	38.0 (1.40)	0.430^b
Respiration rate, (breaths/min)	32.0 (12.00)	26.0 (14.00)	<0.001 ^b
Haematological indices
Hemoglobin, g/dL	5.00 (1.00)	7.95 (3.00)	<0.001 ^b
Hematocrit, %	15.90 (4.30)	25.00 (7.40)	<0.001 ^b
RBC, (× 10¹²/μL)	2.20 (0.86)	3.72 (1.16)	<0.001 ^b
RDW, (%)	23.00 (5.20)	20.45 (4.40)	<0.001 ^b
WBC (×10³/uL)	13.50 (8.80)	10.95 (5.90)	<0.001 ^b
Platelet Counts (×10³/μL)	150.00 (93.00)	170.00 (13.10)	0.025 ^b
Genetic characteristics
G6PD n (%)	8 (7.00)	12 (7.50)	0.880
Sickle cell trait, n (%)	22 (19.30)	46 (28.70)	0.074

Data are presented as the median (interquartile range) and n (%) of children unless stated otherwise. Parasitemic children (n = 274 were categorized as SMA (n = 114) and non-SMA (n = 160) according to modified definition of SMA (Hb < 6.0 g/dL, with any density parasitemia). ^aStatistical significance was determined by the Chi-square (χ²) analysis. ^bStatistical significance was determined using Mann-Whitney U test. ^cStatistical significance was determined using Student’s t-test. Abbreviations: G6PD Glucose-6-Phaspahte dehydrogenase, HDP high density parasitemia, RBC-Red blood cells, RDW - Red cell distribution width; WBC-White blood cells. Probability values were considered statistically significant at P ≤ 0.05
Values in bold are significant p-values at a cut-off of p≤0.05

ISSN: 1471-2334