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Table 3 Comparison between SCCmec types with the patient’s demographic, clinical diagnosis and molecular characteristics of MRSA strains isolated from blood

From: Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection and the molecular characteristics of MRSA bacteraemia over a two-year period in a tertiary teaching hospital in Malaysia

 

SCCmec III

SCCmec IV

SCCmec V

Untypeable

Total

 

N = 60 (%)

N = 27 (%)

N = 2 (%)

N = 2 (%)

N = 91 (%)

Age

  ≤ 50 years old

12 (20)

3 (11.1)

0 (0)

0 (0)

15 (16.5)

  > 50 years old

47 (78.3)

23 (85.2)

2 (100)

2 (100)

74 (81.3)

 Not Known

1 (1.7)

1 (3.7)

0 (0)

0 (0)

2 (2.2)

Gender

 Female

30 (50)

10 (37)

0 (0)

0 (0)

40 (43.9)

 Male

29 (48.3)

16 (59.3)

2 (100)

2 (100)

49 (53.8)

 Not Known

1 (1.7)

1 (3.7)

0 (0)

0 (0)

2 (2.2)

Co-morbidities

 Diabetes mellitus

20 (33.3)

11 (40.7)

1 (50)

0 (0)

32 (35.2)

 Hypertension

22 (36.7)

12 (44.4)

1 (50)

0 (0)

35 (38.5)

 Obesity

0 (0)

1 (3.7)

0 (0)

0 (0)

1 (1.1)

 Chronic kidney disease and UTI

24 (40)

14 (51.9)

0 (0)

0 (0)

38 (41.8)

 Cancer

8 (13.3)

2 (7.4)

0 (0)

0 (0)

10 (10.9)

 Head injury

11 (18.3)

4 (14.8)

0 (0)

1 (50)

16 (17.6)

 Liver disease

4 (6.7)

2 (7.4)

0 (0)

0 (0)

6 (6.6)

 Respiratory disease

12 (20)

3 (11.1)

1 (50)

0 (0)

16 (17.6)

 Cardiovascular disease

4 (6.7)

8 (29.6)

2 (100)

0 (0)

14 (15.4)

 Gastrointestinal disease

4 (6.7)

1 (3.7)

0 (0)

0 (0)

5 (5.5)

 Autoimmune disease

1 (1.7)

0 (0)

0 (0)

0 (0)

1 (1.1)

 Bone and joint disorder

1 (1.7)

2 (7.4)

0 (0)

0 (0)

3 (3.3)

 Endocrine disorder

0 (0)

2 (7.4)

0 (0)

0 (0)

2 (2.2)

 Blood disorder

2 (3.3)

0 (0)

0 (0)

0 (0)

2 (2.2)

 CMV

1 (1.7)

0 (0)

0 (0)

0 (0)

1 (1.1)

 Skin disease

7 (11.7)

0 (0)

0 (0)

0 (0)

7 (7.7)

 None

1 (1.7)

0 (0)

0 (0)

0 (0)

1 (1.1)

 Not known

7 (11.7)

5 (18.5)

0 (0)

1 (50)

13 (14.3)

No of comorbidities

 0

8 (13.3)

5 (18.5)

0 (0)

1 (50)

14 (15.4)

 1

19 (31.7)

5 (18.5)

1 (50)

1 (50)

26 (28.6)

 2

11 (18.3)

6 (22.2)

0 (0)

0 (0)

17 (18.7)

 3

12 (20)

1 (3.7)

0 (0)

0 (0)

13 (14.3)

 ≥ 4

10 (16.7)

10 (37)

1 (50)

0 (0)

21 (23.1)

Source of bacteraemia

 Primary bacteraemia

38 (63.3)

19 (70.4)

2 (100)

2 (100)

61 (67)

 Catheter-related

7 (11.7)

5 (18.5)

0 (0)

0 (0)

12 (13.2)

 Skin and soft tissue infection

6 (10)

0 (0)

0 (0)

0 (0)

6 (6.6)

 Surgical site infection

1 (1.7)

0 (0)

0 (0)

0 (0)

1 (1.1)

 Pneumonia

5 (8.3)

2 (7.4)

0 (0)

0 (0)

7 (7.7)

 Implant-related infection

0 (0)

1 (3.7)

0 (0)

0 (0)

1 (1.1)

 More than one source

3 (5)

0 (0)

0 (0)

0 (0)

3 (3.3)

Type of MRSA

 HA-MRSA

36 (60)

15 (55.6)

0 (0)

0 (0)

51 (56)

 CA-MRSA

15 (25)

9 (33.3)

2 (100)

1 (50)

27 (29.7)

 Not Known

9 (15)

3 (11.1)

0 (0)

1 (50)

13 (14.3)

CC/ST

  CC1

  ST1

0 (0)

1 (3.7)

0 (0)

0 (0)

1 (1.1)

  ST772

0 (0)

0 (0)

1 (50)

0 (0)

1 (1.1)

  CC5

  ST5

0 (0)

0 (0)

1 (50)

0 (0)

1 (1.1)

  CC6

  ST6

0 (0)

6 (22.2)

0 (0)

0 (0)

6 (6.6)

  CC8

  ST239

60 (100)

0 (0)

0 (0)

1 (50)

61 (67)

  CC22

  ST22

0 (0)

19 (70.4)

0 (0)

0 (0)

19 (20.9)

  ST1137

0 (0)

1 (3.7)

0 (0)

0 (0)

1 (1.1)

  CC45

  ST508

0 (0)

0 (0)

0 (0)

1 (50)

1 (1.1)

Vancomycin MIC

  < 1.5 μg/mL

22 (36.7)

25 (92.6)

1 (50)

1 (50)

49 (53.8)

  ≥ 1.5 μg/mL

38 (63.3)

2 (7.4)

1 (50)

1 (50)

42 (46.2)

  1. UTI = Urinary Tract Infection, CMV = Cytomegalovirus
  2. Head injury includes: basal ganglia bleed, subdural hematoma and stroke. Liver disease includes: alcoholic liver disease, liver cirrhosis. Respiratory disease includes: pneumonia, pulmonary embolism, chronic obstructive pulmonary disease, acute respiratory distress syndrome. Cardiovascular disease includes: mitral valve regurgitation, ischaemic heart disease, acute coronary syndrome, congestive cardiac failure. Gastrointestinal disease includes: acute gastroenteritis, Crohn’s disease, perforated diverticular disease, intestinal obstruction. Autoimmune disease includes: Systemic lupus erythematosus. Endocrine disorder includes: thyroid disease, primary hypothyroidism. Blood disorder includes: myelofibrosis, anaemia. Skin disease includes: Stevens Johnson Syndrome, Bullous pemphigoid, exfoliative dermatitis and pemphigus vulgaris
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BMC Infectious Diseases

ISSN: 1471-2334

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