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Table 3 Comparison between SCCmec types with the patient’s demographic, clinical diagnosis and molecular characteristics of MRSA strains isolated from blood

From: Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection and the molecular characteristics of MRSA bacteraemia over a two-year period in a tertiary teaching hospital in Malaysia

  SCCmec III SCCmec IV SCCmec V Untypeable Total
  N = 60 (%) N = 27 (%) N = 2 (%) N = 2 (%) N = 91 (%)
Age
  ≤ 50 years old 12 (20) 3 (11.1) 0 (0) 0 (0) 15 (16.5)
  > 50 years old 47 (78.3) 23 (85.2) 2 (100) 2 (100) 74 (81.3)
 Not Known 1 (1.7) 1 (3.7) 0 (0) 0 (0) 2 (2.2)
Gender
 Female 30 (50) 10 (37) 0 (0) 0 (0) 40 (43.9)
 Male 29 (48.3) 16 (59.3) 2 (100) 2 (100) 49 (53.8)
 Not Known 1 (1.7) 1 (3.7) 0 (0) 0 (0) 2 (2.2)
Co-morbidities
 Diabetes mellitus 20 (33.3) 11 (40.7) 1 (50) 0 (0) 32 (35.2)
 Hypertension 22 (36.7) 12 (44.4) 1 (50) 0 (0) 35 (38.5)
 Obesity 0 (0) 1 (3.7) 0 (0) 0 (0) 1 (1.1)
 Chronic kidney disease and UTI 24 (40) 14 (51.9) 0 (0) 0 (0) 38 (41.8)
 Cancer 8 (13.3) 2 (7.4) 0 (0) 0 (0) 10 (10.9)
 Head injury 11 (18.3) 4 (14.8) 0 (0) 1 (50) 16 (17.6)
 Liver disease 4 (6.7) 2 (7.4) 0 (0) 0 (0) 6 (6.6)
 Respiratory disease 12 (20) 3 (11.1) 1 (50) 0 (0) 16 (17.6)
 Cardiovascular disease 4 (6.7) 8 (29.6) 2 (100) 0 (0) 14 (15.4)
 Gastrointestinal disease 4 (6.7) 1 (3.7) 0 (0) 0 (0) 5 (5.5)
 Autoimmune disease 1 (1.7) 0 (0) 0 (0) 0 (0) 1 (1.1)
 Bone and joint disorder 1 (1.7) 2 (7.4) 0 (0) 0 (0) 3 (3.3)
 Endocrine disorder 0 (0) 2 (7.4) 0 (0) 0 (0) 2 (2.2)
 Blood disorder 2 (3.3) 0 (0) 0 (0) 0 (0) 2 (2.2)
 CMV 1 (1.7) 0 (0) 0 (0) 0 (0) 1 (1.1)
 Skin disease 7 (11.7) 0 (0) 0 (0) 0 (0) 7 (7.7)
 None 1 (1.7) 0 (0) 0 (0) 0 (0) 1 (1.1)
 Not known 7 (11.7) 5 (18.5) 0 (0) 1 (50) 13 (14.3)
No of comorbidities
 0 8 (13.3) 5 (18.5) 0 (0) 1 (50) 14 (15.4)
 1 19 (31.7) 5 (18.5) 1 (50) 1 (50) 26 (28.6)
 2 11 (18.3) 6 (22.2) 0 (0) 0 (0) 17 (18.7)
 3 12 (20) 1 (3.7) 0 (0) 0 (0) 13 (14.3)
 ≥ 4 10 (16.7) 10 (37) 1 (50) 0 (0) 21 (23.1)
Source of bacteraemia
 Primary bacteraemia 38 (63.3) 19 (70.4) 2 (100) 2 (100) 61 (67)
 Catheter-related 7 (11.7) 5 (18.5) 0 (0) 0 (0) 12 (13.2)
 Skin and soft tissue infection 6 (10) 0 (0) 0 (0) 0 (0) 6 (6.6)
 Surgical site infection 1 (1.7) 0 (0) 0 (0) 0 (0) 1 (1.1)
 Pneumonia 5 (8.3) 2 (7.4) 0 (0) 0 (0) 7 (7.7)
 Implant-related infection 0 (0) 1 (3.7) 0 (0) 0 (0) 1 (1.1)
 More than one source 3 (5) 0 (0) 0 (0) 0 (0) 3 (3.3)
Type of MRSA
 HA-MRSA 36 (60) 15 (55.6) 0 (0) 0 (0) 51 (56)
 CA-MRSA 15 (25) 9 (33.3) 2 (100) 1 (50) 27 (29.7)
 Not Known 9 (15) 3 (11.1) 0 (0) 1 (50) 13 (14.3)
CC/ST
CC1
  ST1 0 (0) 1 (3.7) 0 (0) 0 (0) 1 (1.1)
  ST772 0 (0) 0 (0) 1 (50) 0 (0) 1 (1.1)
CC5
  ST5 0 (0) 0 (0) 1 (50) 0 (0) 1 (1.1)
CC6
  ST6 0 (0) 6 (22.2) 0 (0) 0 (0) 6 (6.6)
CC8
  ST239 60 (100) 0 (0) 0 (0) 1 (50) 61 (67)
CC22
  ST22 0 (0) 19 (70.4) 0 (0) 0 (0) 19 (20.9)
  ST1137 0 (0) 1 (3.7) 0 (0) 0 (0) 1 (1.1)
CC45
  ST508 0 (0) 0 (0) 0 (0) 1 (50) 1 (1.1)
Vancomycin MIC
  < 1.5 μg/mL 22 (36.7) 25 (92.6) 1 (50) 1 (50) 49 (53.8)
  ≥ 1.5 μg/mL 38 (63.3) 2 (7.4) 1 (50) 1 (50) 42 (46.2)
  1. UTI = Urinary Tract Infection, CMV = Cytomegalovirus
  2. Head injury includes: basal ganglia bleed, subdural hematoma and stroke. Liver disease includes: alcoholic liver disease, liver cirrhosis. Respiratory disease includes: pneumonia, pulmonary embolism, chronic obstructive pulmonary disease, acute respiratory distress syndrome. Cardiovascular disease includes: mitral valve regurgitation, ischaemic heart disease, acute coronary syndrome, congestive cardiac failure. Gastrointestinal disease includes: acute gastroenteritis, Crohn’s disease, perforated diverticular disease, intestinal obstruction. Autoimmune disease includes: Systemic lupus erythematosus. Endocrine disorder includes: thyroid disease, primary hypothyroidism. Blood disorder includes: myelofibrosis, anaemia. Skin disease includes: Stevens Johnson Syndrome, Bullous pemphigoid, exfoliative dermatitis and pemphigus vulgaris