Table 1 Overview of characteristics of included randomized trials

Median (range)

352 (37–27,830)

Year of publication (median, range)

Median 2005 (range 1968–2016)

Before 1980

3 (10%)

1981–1990

1 (3.3%)

1991–2000

6 (20%)

2001–2010

10 (33.3%)

2011–2016

10 (33.3%)

% Female participants

Median (range)

45.5% (0%–83.3%)

Average patient age (years)

# studies reporting mean/median

23

# with average age between <20

3 (13.0%)

# with average age between 20 and 40

13 (56.5%)

# with average age > 40

7 (30.5%)

Other population characteristics of note

# enrolling HIV patients

5 (17.2%)

# in prison populations

2 (6.9%)

# in population at risk of silicosis

3 (10.3%)

# in transplant patients

1 (3.5%)

Funding source

Industry

3 (10%)

Academic/government

15 (50%)

Mixed funding

1 (3.3%)

Not reported

11 (36.7%)