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Table 5 Association of variables with subsequent hemodialysis requirement in patients with severe malaria

From: Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

  Univariable analysis Multivariable F2-IsoP model Multivariable IsoF model
Variable OR (95% CI)a P OR (95% CI)a P OR (95% CI)a P
CFH 1.01 (0.99 to 1.03) 0.063 --- --- 1.06 (0.98 to 1.14) 0.156
Log F2-IsoP# 3.45 (1.30 to 9.16) 0.013 7.37 (1.86 to 29.23) 0.005 --- ---
Log IsoF 3.48 (1.62 to 7.49) 0.001 --- --- 5.50 (1.76 to 17.24) 0.003
LogPfHRP2 1.92 (1.27 to 2.91) 0.002 --- --- --- ---
LogRCD at SS 1.69 Pa 0.29 (0.08 to 1.09) 0.066 --- --- --- ---
LogRCD at SS 9.49 Pa 0.10 (0.01 to 0.75) 0.025 0.057 (0.002 to 1.33) 0.075 0.031 (0.001 to 1.44) 0.076
Age 1.00 (0.97 to 1.03) 0.940 --- --- --- ---
SBP 1.02 (0.99 to 1.04) 0.260    --- ---
Number of severity criteria 1.90 (1.38 to 2.62) <0.001 --- --- --- ---
GCS 0.95 (0.85 to 1.07) 0.393 --- --- --- ---
LogLactate 1.22 (0.64 to 2.30) 0.548 --- --- --- ---
  1. aOdds ratio (OR) with 95% confidence intervals (CIs) showing the hemodialysis requirement predicted by a 1-U change in the independent (predictor) variables. A backward stepwise multivariable model included all variables in univariable analyses which were removed on the basis of P ≥ 0.05. Abbreviations: CFH cell free hemoglobin, F 2 -IsoP plasma F2-isoprostanes, IsoF plasma isofurans, PfHRP2 P. falciparum histidine rich protein 2, RCD red cell deformability at shear stress 1.69 and 9.49 Pa, SBP systolic blood pressure, GCS Glasgow Coma Score. # Plasma IsoFs collinear with plasma F2- IsoPs. P-values in italics denote statistical significance