| |
Univariable analysis
|
Multivariable F2-IsoP model
|
Multivariable IsoF model
|
|---|
|
Variable
|
β (95% CI)a
|
P
|
β (95% CI)a
|
P
|
β (95% CI)a
|
P
|
|---|
|
Log CFH§
|
0.27 (−0.19 to 0.74)
|
0.249
|
---
|
---
|
---
|
---
|
|
Log F2-IsoP#
|
2.35 (1.27 to 3.43)
|
<0.001
|
3.01 (1.92 to 4.12)
|
<0.001
|
---
|
---
|
|
Log IsoF
|
2.06 (1.46 to 2.65)
|
<0.001
|
---
|
---
|
1.83 (1.26 to 2.40)
|
<0.001
|
|
LogPfHRP2
|
0.61 (0.25 to 0.98)
|
0.001
|
0.70 (0.02 to 1.38)
|
0.045
|
0.69 (0.05 to 1.32)
|
0.034
|
|
RCD at SS 1.69 Pa
|
−1.67 (−14.93 to 11.59)
|
0.805
|
---
|
---
|
---
|
---
|
|
RCD at SS 9.49 Pa
|
−6.42 (−15.10 to 2.26)
|
0.147
|
−4.26 (−7.86 to −0.67)
|
0.020
|
−2.46 (−5.92 to 1.00)
|
0.163
|
|
Age
|
0.01 (−0.03 to 0.05)
|
0.624
|
---
|
---
|
---
|
---
|
|
SBP
|
0.03 (−0.01 to 0.06)
|
0.094
| | |
---
|
---
|
|
Visit (time)
|
0.65 (0.52 to 0.78)
|
<0.001
|
---
|
---
|
---
|
---
|
|
Log CFH × Log F2-IsoP
|
0.31 (−0.19 to 0.86)
|
0.221
|
---
|
---
|
---
|
---
|
|
Log CFH × Log IsoF
|
0.62 (0.27 to 0.98)
|
0.001
|
---
|
---
|
---
|
---
|
|
Log F2-IsoP × visit
|
0.85 (0.55 to 1.14)
|
<0.001
|
---
|
---
|
---
|
---
|
|
Log IsoF × visit
|
0.62 (0.47 to 0.76)
|
<0.001
|
---
|
---
|
---
|
---
|
|
Log CFH × visit
|
0.10 (−0.10 to 0.21)
|
0.076
|
0.21 (0.05 to 0.36)
|
0.010
|
0.20 (0.04 to 0.36)
|
0.012
|
-
aRegression coefficient (β) with 95% confidence intervals (CIs) showing the estimated decrease in creatinine predicted by a 1-U change in the independent (predictor) variables. Interaction terms improved the model fit. Abbreviations: CFH cell free hemoglobin, F
2
-IsoP plasma F2-isoprostanes, IsoF plasma isofurans, CFH × F
2
-IsoP cell-free hemoglobin and plasma F2-isoprostane interaction term, CFH × IsoF cell-free hemoglobin and plasma isofuran interaction term, PfHRP2 P. falciparum histidine rich protein 2, RCD red cell deformability at shear stress 1.69 and 9.49 Pa. # Plasma IsoFs collinear with plasma F2- IsoPs. P-values in italics denote statistical significance
