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Table 4 Association of variables with change in absolute creatinine over 72 h in patients with severe malaria

From: Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

 

Univariable analysis

Multivariable F2-IsoP model

Multivariable IsoF model

Variable

β (95% CI)a

P

β (95% CI)a

P

β (95% CI)a

P

Log CFH§

0.27 (−0.19 to 0.74)

0.249

---

---

---

---

Log F2-IsoP#

2.35 (1.27 to 3.43)

<0.001

3.01 (1.92 to 4.12)

<0.001

---

---

Log IsoF

2.06 (1.46 to 2.65)

<0.001

---

---

1.83 (1.26 to 2.40)

<0.001

LogPfHRP2

0.61 (0.25 to 0.98)

0.001

0.70 (0.02 to 1.38)

0.045

0.69 (0.05 to 1.32)

0.034

RCD at SS 1.69 Pa

−1.67 (−14.93 to 11.59)

0.805

---

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---

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RCD at SS 9.49 Pa

−6.42 (−15.10 to 2.26)

0.147

−4.26 (−7.86 to −0.67)

0.020

−2.46 (−5.92 to 1.00)

0.163

Age

0.01 (−0.03 to 0.05)

0.624

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SBP

0.03 (−0.01 to 0.06)

0.094

  

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Visit (time)

0.65 (0.52 to 0.78)

<0.001

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---

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Log CFH × Log F2-IsoP

0.31 (−0.19 to 0.86)

0.221

---

---

---

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Log CFH × Log IsoF

0.62 (0.27 to 0.98)

0.001

---

---

---

---

Log F2-IsoP × visit

0.85 (0.55 to 1.14)

<0.001

---

---

---

---

Log IsoF × visit

0.62 (0.47 to 0.76)

<0.001

---

---

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Log CFH × visit

0.10 (−0.10 to 0.21)

0.076

0.21 (0.05 to 0.36)

0.010

0.20 (0.04 to 0.36)

0.012

  1. aRegression coefficient (β) with 95% confidence intervals (CIs) showing the estimated decrease in creatinine predicted by a 1-U change in the independent (predictor) variables. Interaction terms improved the model fit. Abbreviations: CFH cell free hemoglobin, F 2 -IsoP plasma F2-isoprostanes, IsoF plasma isofurans, CFH × F 2 -IsoP cell-free hemoglobin and plasma F2-isoprostane interaction term, CFH × IsoF cell-free hemoglobin and plasma isofuran interaction term, PfHRP2 P. falciparum histidine rich protein 2, RCD red cell deformability at shear stress 1.69 and 9.49 Pa. # Plasma IsoFs collinear with plasma F2- IsoPs. P-values in italics denote statistical significance