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Table 3 Outcomes by AKI status on enrolment

From: Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

Outcome Total No AKI AKI P
  (n = 107) (n = 45) (n = 62)  
AKI stage during admission†
 Stage 1 (≥1.5 × baseline)c 11 (12) 4 (10) 7 (15) 0.458
 Stage 2 (≥2.0–2.9 × baseline)c 11 (12) 1 (2) 10 (21) 0.021
 Stage 3 (≥3.0 × baseline or ≥4 mg/dl)c 36 (40) 5 (12) 31 (65) <0.001
Received RRT (%)c 32 (30) 3 (7) 29 (47) <0.001
Length of hospital stay (days) 7.6 (5.6–12.9) 5.9 (4.9–8.3) 10.6 (6.6–18.0) <0.001
Death (%)c 35 (33) 10 (22) 25 (40) 0.061
Study hours to death (%)c 22.5 (12.5–51.0) 40.1 (19.0–115.0) 21.0 (10.0–38.0) 0.074
  1. All values are median (IQR) unless otherwise specified: cnumber (%). P < 0.05 using Mann U Whitney or Fischer’s exact test; significant in bold. †Highest KDIGO stage during admission in those that survived more than 24 h. Abbreviations: AKI = acute kidney injury; RRT = renal replacement therapy