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Table 3 Outcomes by AKI status on enrolment

From: Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

Outcome

Total

No AKI

AKI

P

 

(n = 107)

(n = 45)

(n = 62)

 

AKI stage during admission†

 Stage 1 (≥1.5 × baseline)c

11 (12)

4 (10)

7 (15)

0.458

 Stage 2 (≥2.0–2.9 × baseline)c

11 (12)

1 (2)

10 (21)

0.021

 Stage 3 (≥3.0 × baseline or ≥4 mg/dl)c

36 (40)

5 (12)

31 (65)

<0.001

Received RRT (%)c

32 (30)

3 (7)

29 (47)

<0.001

Length of hospital stay (days)

7.6 (5.6–12.9)

5.9 (4.9–8.3)

10.6 (6.6–18.0)

<0.001

Death (%)c

35 (33)

10 (22)

25 (40)

0.061

Study hours to death (%)c

22.5 (12.5–51.0)

40.1 (19.0–115.0)

21.0 (10.0–38.0)

0.074

  1. All values are median (IQR) unless otherwise specified: cnumber (%). P < 0.05 using Mann U Whitney or Fischer’s exact test; significant in bold. †Highest KDIGO stage during admission in those that survived more than 24 h. Abbreviations: AKI = acute kidney injury; RRT = renal replacement therapy