Fig. 1

Correlation of oxidative stress markers in severe malaria. a Parasite burden, as measured by PfHRP2 concentration, positively correlated with plasma cell-free hemoglobin concentration (n = 96), b cell-free hemoglobin positively correlated with plasma F2-isoprostanes (n = 62). Acidemia (venous pH) was inversely correlated with (c) plasma F2-isoprostanes, and d plasma isofurans. All values are from enrolment assessments. Abbreviations: PfHRP2, Plasmodium falciparum histidine rich protein 2; r s , Spearman’s correlation coefficient