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Table 2 Predictive performance of various BDG levels for diagnosing candidemia and suspected CP in different specimens

From: Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study

Cutoff value Sensitivity Specificity PPV NPV
Candidemia
Serum BDG, pg/ml
 70 100% 100% 100% 100%
 80 100% 100% 100% 100%
 90 75% 100% 100% 96%
Suspected CP
TA BDG, pg/mla
 90 89% 55% 44% 92%
 100 89% 59% 47% 93%
 110 78% 68% 50% 88%
 120 67% 82% 60% 86%
 130 0% 70% 0% 83%
BAL BDG, pg/ml
 110 89% 73% 57% 94%
 120 89% 77% 62% 94%
 130 89% 86% 73% 95%
 140 89% 91% 80% 95%
 150 67% 91% 75% 95%
Serum BDG, pg/ml
 20 67% 41% 32% 75%
 25 33% 59% 25% 68%
 30 0% 73% 0% 64%
  1. PPV positive predictive value, NPV negative predictive value, BDG β-D-glucan
  2. Refer to Table 1 for other abbreviations
  3. aAdjusted to per gram of endotracheal aspirate