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Table 2 Predictive performance of various BDG levels for diagnosing candidemia and suspected CP in different specimens

From: Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study

Cutoff value

Sensitivity

Specificity

PPV

NPV

Candidemia

Serum BDG, pg/ml

 70

100%

100%

100%

100%

 80

100%

100%

100%

100%

 90

75%

100%

100%

96%

Suspected CP

TA BDG, pg/mla

 90

89%

55%

44%

92%

 100

89%

59%

47%

93%

 110

78%

68%

50%

88%

 120

67%

82%

60%

86%

 130

0%

70%

0%

83%

BAL BDG, pg/ml

 110

89%

73%

57%

94%

 120

89%

77%

62%

94%

 130

89%

86%

73%

95%

 140

89%

91%

80%

95%

 150

67%

91%

75%

95%

Serum BDG, pg/ml

 20

67%

41%

32%

75%

 25

33%

59%

25%

68%

 30

0%

73%

0%

64%

  1. PPV positive predictive value, NPV negative predictive value, BDG β-D-glucan
  2. Refer to Table 1 for other abbreviations
  3. aAdjusted to per gram of endotracheal aspirate