Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

Paridhi Gupta; Anuj Sharma; Jing Han; Amy Yang; Manish Bhomia; Barbara Knollmann-Ritschel; Raj K Puri; Radha K Maheshwari

doi:10.1186/s12879-017-2355-3

BMC Infectious Diseases

Table 5 Significantly modulated genes in brain unique to V3034 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene	Gene	Description	Log₂ Exp ± SEM
Genes uniquely modulated at 48 h pi
Mm.40655	Fam185a	Family with sequence similarity 185, member A	2.97 ± 0.56
Mm.57138	Six6	Sine oculis-related homeobox 6 homolog	2.57 ± 0.57
Mm.141021	Ifitm3	Interferon induced transmembrane protein 3	2.54 ± 0.31
Mm.46418	Chia	Chitinase, acidic	2.34 ± 0.38
Mm.44176	Efemp1	Epidermal growth factor-containing fibulin-like extracellular matrix protein 1	1.79 ± 0.28
Mm.103748	Extl3	Exostoses (multiple)-like 3	1.62 ± 0.28
Mm.207062	Hoxc13	Homeobox C13	1.59 ± 0.28
Mm.28162	Nup210	Nucleoporin 210	1.53 ± 0.16
Mm.41075	Drd4	Dopamine receptor D4	1.51 ± 0.22
Mm.42150	Rasgrp1	RAS guanyl releasing protein 1	1.44 ± 0.31
Genes uniquely modulated at 72 h pi
Mm.40965	Nt5c2	5′-nucleotidase, cytosolic II	4.22 ± 0.85
Mm.461583	Zfp456	Zinc finger protein 456	3.18 ± 0.52
Mm.196581	Mapk1	Mitogen-activated protein kinase 1	2.75 ± 0.29
Mm.57138	Six6	Sine oculis-related homeobox 6 homolog	2.70 ± 0.37
Mm.460823	Gm10731	Predicted gene 10,731	2.66 ± 0.29
Mm.357727	Gm46	PREDICTED: predicted gene 46	2.66 ± 0.45
Mm.364180	5033411D12Rik	RIKEN cDNA 5033411D12 gene	2.54 ± 0.37
Mm.426537	LOC100041885	PREDICTED: sp110 nuclear body protein-like	2.50 ± 0.40
Mm.245154	Tmeff2	Transmembrane protein with EGF-like and two follistatin-like domains 2	2.13 ± 0.30
Mm.276739	Sox10	SRY-box containing gene 10	1.99 ± 0.35
Genes uniquely modulated at 96 h pi
Mm.57138	Six6	Sine oculis-related homeobox 6 homolog	3.24 ± 0.13
Mm.196581	Mapk1	Mitogen-activated protein kinase 1	2.85 ± 0.19
Mm.196013	Samd9l	Sterile alpha motif domain containing 9-like	2.21 ± 0.08
Mm.41075	Drd4	Dopamine receptor D4	2.18 ± 0.13
Mm.32881	Spnb1	Spectrin beta 1	2.02 ± 0.18
Mm.323595	Tob2	Transducer of ERBB2, 2	1.76 ± 0.19
Mm.256414	Slc9a2	Solute carrier family 9 (sodium/hydrogen exchanger), member 2	1.64 ± 0.13
Mm.269029	Slc7a6os	Solute carrier family 7, member 6 opposite strand	1.61 ± 0.24
Mm.34428	Pias4	Protein inhibitor of activated STAT 4	1.38 ± 0.02
Mm.271745	Nrp1	Neuropilin 1	1.30 ± 0.08

Genes that were uniquely modulated against V3034 infection in the brain were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log₂) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05

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