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Table 5 Significantly modulated genes in brain unique to V3034 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene Gene Description Log2 Exp ± SEM
Genes uniquely modulated at 48 h pi
 Mm.40655 Fam185a Family with sequence similarity 185, member A 2.97 ± 0.56
 Mm.57138 Six6 Sine oculis-related homeobox 6 homolog 2.57 ± 0.57
 Mm.141021 Ifitm3 Interferon induced transmembrane protein 3 2.54 ± 0.31
 Mm.46418 Chia Chitinase, acidic 2.34 ± 0.38
 Mm.44176 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 1.79 ± 0.28
 Mm.103748 Extl3 Exostoses (multiple)-like 3 1.62 ± 0.28
 Mm.207062 Hoxc13 Homeobox C13 1.59 ± 0.28
 Mm.28162 Nup210 Nucleoporin 210 1.53 ± 0.16
 Mm.41075 Drd4 Dopamine receptor D4 1.51 ± 0.22
 Mm.42150 Rasgrp1 RAS guanyl releasing protein 1 1.44 ± 0.31
Genes uniquely modulated at 72 h pi
 Mm.40965 Nt5c2 5′-nucleotidase, cytosolic II 4.22 ± 0.85
 Mm.461583 Zfp456 Zinc finger protein 456 3.18 ± 0.52
 Mm.196581 Mapk1 Mitogen-activated protein kinase 1 2.75 ± 0.29
 Mm.57138 Six6 Sine oculis-related homeobox 6 homolog 2.70 ± 0.37
 Mm.460823 Gm10731 Predicted gene 10,731 2.66 ± 0.29
 Mm.357727 Gm46 PREDICTED: predicted gene 46 2.66 ± 0.45
 Mm.364180 5033411D12Rik RIKEN cDNA 5033411D12 gene 2.54 ± 0.37
 Mm.426537 LOC100041885 PREDICTED: sp110 nuclear body protein-like 2.50 ± 0.40
 Mm.245154 Tmeff2 Transmembrane protein with EGF-like and two follistatin-like domains 2 2.13 ± 0.30
 Mm.276739 Sox10 SRY-box containing gene 10 1.99 ± 0.35
Genes uniquely modulated at 96 h pi
 Mm.57138 Six6 Sine oculis-related homeobox 6 homolog 3.24 ± 0.13
 Mm.196581 Mapk1 Mitogen-activated protein kinase 1 2.85 ± 0.19
 Mm.196013 Samd9l Sterile alpha motif domain containing 9-like 2.21 ± 0.08
 Mm.41075 Drd4 Dopamine receptor D4 2.18 ± 0.13
 Mm.32881 Spnb1 Spectrin beta 1 2.02 ± 0.18
 Mm.323595 Tob2 Transducer of ERBB2, 2 1.76 ± 0.19
 Mm.256414 Slc9a2 Solute carrier family 9 (sodium/hydrogen exchanger), member 2 1.64 ± 0.13
 Mm.269029 Slc7a6os Solute carrier family 7, member 6 opposite strand 1.61 ± 0.24
 Mm.34428 Pias4 Protein inhibitor of activated STAT 4 1.38 ± 0.02
 Mm.271745 Nrp1 Neuropilin 1 1.30 ± 0.08
  1. Genes that were uniquely modulated against V3034 infection in the brain were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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