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Table 4 Significantly modulated genes in spleen unique to V3034 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene Gene Description Log2 Exp ± SEM
Genes uniquely modulated at 24 h pi
 Mm.276926 Prss2 Protease, serine, 2 5.61 ± 0.83
 Mm.45316 Cela2a Chymotrypsin-like elastase family, member 2A 5.17 ± 0.20
 Mm.297477 Cela3b Chymotrypsin-like elastase family, member 3B 5.10 ± 0.29
 Mm.243758 Apol9a Apolipoprotein L 9a 3.89 ± 0.66
 Mm.4950 Isg15 ISG15 ubiquitin-like modifier 3.47 ± 0.38
 Mm.33902 Igtp Interferon gamma induced GTPase 3.10 ± 0.39
 Mm.23067 Ufm1 Ubiquitin-fold modifier 1 2.43 ± 0.49
 Mm.32881 Spnb1 Spectrin beta 1 2.19 ± 0.45
 Mm.439732 C1qc Complement component 1, q subcomponent, C chain 1.91 ± 0.32
 Mm.259916 Chdh Choline dehydrogenase 1.86 ± 0.08
Genes uniquely modulated at 48 h pi
 Mm.9714 Gdf9 Growth differentiation factor 9 4.80 ± 1.03
 Mm.376121 Olfr1152 Olfactory receptor 1152 3.57 ± 0.49
 Mm.132226 Ehd4 EH-domain containing 4 2.71 ± 0.22
 Mm.386931 Ecm2 Extracellular matrix protein 2, female organ and adipocyte specific 2.25 ± 0.04
 Mm.302516 Fsip2 PREDICTED: fibrous sheath-interacting protein 2 2.19 ± 0.34
 Mm.483584 Serpina3f Serine (or cysteine) peptidase inhibitor, clade A, member 3F 2.08 ± 0.20
 Mm.447 Pyhin1 Pyrin and HIN domain family, member 1 2.04 ± 0.28
 Mm.265806 Ankrd13c Ankyrin repeat domain 13c 1.89 ± 0.12
 Mm.90450 Myo1a Myosin IA 1.84 ± 0.02
 Mm.41337 Akr1c18 Aldo-keto reductase family 1, member C18 1.84 ± 0.14
Genes uniquely modulated at 72 h pi
 Mm.297477 Cela3b Chymotrypsin-like elastase family, member 3B 6.33 ± 0.59
 Mm.45316 Cela2a Chymotrypsin-like elastase family, member 2A 6.24 ± 0.26
 Mm.485316 Gm5409 Predicted pseudogene 5409 6.11 ± 0.50
 Mm.276926 Prss2 Protease, serine, 2 6.01 ± 0.55
 Mm.8369 Mst1 Macrophage stimulating 1 5.87 ± 0.50
 Mm.212333 Pnliprp2 Pancreatic lipase-related protein 2 5.59 ± 0.66
 Mm.389688 Oas1g 2′-5′ oligoadenylate synthetase 1G 4.85 ± 0.45
 Mm.245154 Tmeff2 Transmembrane protein with EGF-like and two follistatin-like domains 2 4.32 ± 0.45
 Mm.2745 Ctrl Chymotrypsin-like 3.77 ± 0.67
 Mm.243758 Apol9a Apolipoprotein L 9a 3.27 ± 0.23
  1. Genes that were uniquely modulated against V3034 infection in the spleen were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05