Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

Gupta, Paridhi; Sharma, Anuj; Han, Jing; Yang, Amy; Bhomia, Manish; Knollmann-Ritschel, Barbara; Puri, Raj K; Maheshwari, Radha K

doi:10.1186/s12879-017-2355-3

Table 4 Significantly modulated genes in spleen unique to V3034 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene	Gene	Description	Log₂ Exp ± SEM
Genes uniquely modulated at 24 h pi
Mm.276926	Prss2	Protease, serine, 2	5.61 ± 0.83
Mm.45316	Cela2a	Chymotrypsin-like elastase family, member 2A	5.17 ± 0.20
Mm.297477	Cela3b	Chymotrypsin-like elastase family, member 3B	5.10 ± 0.29
Mm.243758	Apol9a	Apolipoprotein L 9a	3.89 ± 0.66
Mm.4950	Isg15	ISG15 ubiquitin-like modifier	3.47 ± 0.38
Mm.33902	Igtp	Interferon gamma induced GTPase	3.10 ± 0.39
Mm.23067	Ufm1	Ubiquitin-fold modifier 1	2.43 ± 0.49
Mm.32881	Spnb1	Spectrin beta 1	2.19 ± 0.45
Mm.439732	C1qc	Complement component 1, q subcomponent, C chain	1.91 ± 0.32
Mm.259916	Chdh	Choline dehydrogenase	1.86 ± 0.08
Genes uniquely modulated at 48 h pi
Mm.9714	Gdf9	Growth differentiation factor 9	4.80 ± 1.03
Mm.376121	Olfr1152	Olfactory receptor 1152	3.57 ± 0.49
Mm.132226	Ehd4	EH-domain containing 4	2.71 ± 0.22
Mm.386931	Ecm2	Extracellular matrix protein 2, female organ and adipocyte specific	2.25 ± 0.04
Mm.302516	Fsip2	PREDICTED: fibrous sheath-interacting protein 2	2.19 ± 0.34
Mm.483584	Serpina3f	Serine (or cysteine) peptidase inhibitor, clade A, member 3F	2.08 ± 0.20
Mm.447	Pyhin1	Pyrin and HIN domain family, member 1	2.04 ± 0.28
Mm.265806	Ankrd13c	Ankyrin repeat domain 13c	1.89 ± 0.12
Mm.90450	Myo1a	Myosin IA	1.84 ± 0.02
Mm.41337	Akr1c18	Aldo-keto reductase family 1, member C18	1.84 ± 0.14
Genes uniquely modulated at 72 h pi
Mm.297477	Cela3b	Chymotrypsin-like elastase family, member 3B	6.33 ± 0.59
Mm.45316	Cela2a	Chymotrypsin-like elastase family, member 2A	6.24 ± 0.26
Mm.485316	Gm5409	Predicted pseudogene 5409	6.11 ± 0.50
Mm.276926	Prss2	Protease, serine, 2	6.01 ± 0.55
Mm.8369	Mst1	Macrophage stimulating 1	5.87 ± 0.50
Mm.212333	Pnliprp2	Pancreatic lipase-related protein 2	5.59 ± 0.66
Mm.389688	Oas1g	2′-5′ oligoadenylate synthetase 1G	4.85 ± 0.45
Mm.245154	Tmeff2	Transmembrane protein with EGF-like and two follistatin-like domains 2	4.32 ± 0.45
Mm.2745	Ctrl	Chymotrypsin-like	3.77 ± 0.67
Mm.243758	Apol9a	Apolipoprotein L 9a	3.27 ± 0.23

Genes that were uniquely modulated against V3034 infection in the spleen were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log₂) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05

Back to article page

ISSN: 1471-2334

Contact us

Submission enquiries: bmcinfectiousdiseases@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Infectious Diseases

Contact us