Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

Paridhi Gupta; Anuj Sharma; Jing Han; Amy Yang; Manish Bhomia; Barbara Knollmann-Ritschel; Raj K Puri; Radha K Maheshwari

doi:10.1186/s12879-017-2355-3

BMC Infectious Diseases

Table 3 Significantly modulated genes in brain unique to V3000 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene	Gene	Description	Log₂ Exp ± SEM
Genes uniquely modulated at 48 h pi
Mm.40965	Nt5c2	5′-nucleotidase, cytosolic II	3.44 ± 0.61
Mm.461583	Zfp456	Zinc finger protein 456	2.79 ± 0.56
Mm.341423	Dock4	Dedicator of cytokinesis 4	2.16 ± 0.05
Mm.338001	Pld5	Phospholipase D family, member 5	1.90 ± 0.21
Mm.33902	Igtp	Interferon gamma induced GTPase	1.84 ± 0.26
Mm.211477	Phldb2	Pleckstrin homology-like domain, family B, member 2	1.76 ± 0.13
Mm.247453	Abhd10	Abhydrolase domain containing 10	1.50 ± 0.22
Mm.6856	Pttg1	Pituitary tumor-transforming gene 1	1.46 ± 0.04
Mm.290764	Lrrc61	Leucine rich repeat containing 61	1.43 ± 0.26
Mm.442861	H2-D4	Histocompatibility 2, D region locus 4	1.40 ± 0.15
Genes uniquely modulated at 72 h pi
Mm.141021	Ifitm3	Interferon induced transmembrane protein 3	2.98 ± 0.37
Mm.425949	Ly6a	Lymphocyte antigen 6 complex, locus A	2.64 ± 0.46
Mm.44176	Efemp1	Epidermal growth factor-containing fibulin-like extracellular matrix protein 1	2.44 ± 0.17
Mm.439743	H2-Q7	Histocompatibility 2, Q region locus 7	2.35 ± 0.13
Mm.132226	Ehd4	EH-domain containing 4	2.05 ± 0.30
Mm.41075	Drd4	Dopamine receptor 4	1.97 ± 0.15
Mm.39825	Lmx1b	LIM homeobox transcription factor 1 beta	1.84 ± 0.12
Mm.131422	Osm	Oncostatin M	1.67 ± 0.26
Mm.475107	Rtp4	Receptor transporter protein 4	1.51 ± 0.10
Mm.69751	Pepd	Peptidase D	1.44 ± 0.11
Genes uniquely modulated at 96 h pi
Mm.4950	Isg15	ISG15 ubiquitin-like modifier	4.04 ± 0.46
Mm.425949	Ly6a	Lymphocyte antigen 6 complex, locus A	3.89 ± 0.12
Mm.284248	Ccl5	Chemokine (C-C motif) ligand 5	3.76 ± 0.69
Mm.290320	Ccl2	Chemokine (C-C motif) ligand 2	2.80 ± 0.25
Mm.24045	Rsad2	Radical S-adenosyl methionine domain containing 2	2.74 ± 0.57
Mm.133342	Rnf213	Ring finger protein 213	2.66 ± 0.37
Mm.24125	Col4a3bp	Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	2.59 ± 0.43
Mm.426537	LOC100041885	PREDICTED: similar to C130026I21Rik protein	2.45 ± 0.19
Mm.439648	H2-T23	Histocompatibility 2, T region locus 23	2.32 ± 0.44
Mm.357727	Gm46	PREDICTED: gene model 46, (NCBI)	2.31 ± 0.23

Genes that were uniquely modulated against V3000 infection in the brain were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log₂) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05

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