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Table 3 Significantly modulated genes in brain unique to V3000 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene

Gene

Description

Log2 Exp ± SEM

Genes uniquely modulated at 48 h pi

 Mm.40965

Nt5c2

5′-nucleotidase, cytosolic II

3.44 ± 0.61

 Mm.461583

Zfp456

Zinc finger protein 456

2.79 ± 0.56

 Mm.341423

Dock4

Dedicator of cytokinesis 4

2.16 ± 0.05

 Mm.338001

Pld5

Phospholipase D family, member 5

1.90 ± 0.21

 Mm.33902

Igtp

Interferon gamma induced GTPase

1.84 ± 0.26

 Mm.211477

Phldb2

Pleckstrin homology-like domain, family B, member 2

1.76 ± 0.13

 Mm.247453

Abhd10

Abhydrolase domain containing 10

1.50 ± 0.22

 Mm.6856

Pttg1

Pituitary tumor-transforming gene 1

1.46 ± 0.04

 Mm.290764

Lrrc61

Leucine rich repeat containing 61

1.43 ± 0.26

 Mm.442861

H2-D4

Histocompatibility 2, D region locus 4

1.40 ± 0.15

Genes uniquely modulated at 72 h pi

 Mm.141021

Ifitm3

Interferon induced transmembrane protein 3

2.98 ± 0.37

 Mm.425949

Ly6a

Lymphocyte antigen 6 complex, locus A

2.64 ± 0.46

 Mm.44176

Efemp1

Epidermal growth factor-containing fibulin-like extracellular matrix protein 1

2.44 ± 0.17

 Mm.439743

H2-Q7

Histocompatibility 2, Q region locus 7

2.35 ± 0.13

 Mm.132226

Ehd4

EH-domain containing 4

2.05 ± 0.30

 Mm.41075

Drd4

Dopamine receptor 4

1.97 ± 0.15

 Mm.39825

Lmx1b

LIM homeobox transcription factor 1 beta

1.84 ± 0.12

 Mm.131422

Osm

Oncostatin M

1.67 ± 0.26

 Mm.475107

Rtp4

Receptor transporter protein 4

1.51 ± 0.10

 Mm.69751

Pepd

Peptidase D

1.44 ± 0.11

Genes uniquely modulated at 96 h pi

 Mm.4950

Isg15

ISG15 ubiquitin-like modifier

4.04 ± 0.46

 Mm.425949

Ly6a

Lymphocyte antigen 6 complex, locus A

3.89 ± 0.12

 Mm.284248

Ccl5

Chemokine (C-C motif) ligand 5

3.76 ± 0.69

 Mm.290320

Ccl2

Chemokine (C-C motif) ligand 2

2.80 ± 0.25

 Mm.24045

Rsad2

Radical S-adenosyl methionine domain containing 2

2.74 ± 0.57

 Mm.133342

Rnf213

Ring finger protein 213

2.66 ± 0.37

 Mm.24125

Col4a3bp

Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

2.59 ± 0.43

 Mm.426537

LOC100041885

PREDICTED: similar to C130026I21Rik protein

2.45 ± 0.19

 Mm.439648

H2-T23

Histocompatibility 2, T region locus 23

2.32 ± 0.44

 Mm.357727

Gm46

PREDICTED: gene model 46, (NCBI)

2.31 ± 0.23

  1. Genes that were uniquely modulated against V3000 infection in the brain were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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