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Table 3 Significantly modulated genes in brain unique to V3000 infection

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene Gene Description Log2 Exp ± SEM
Genes uniquely modulated at 48 h pi
 Mm.40965 Nt5c2 5′-nucleotidase, cytosolic II 3.44 ± 0.61
 Mm.461583 Zfp456 Zinc finger protein 456 2.79 ± 0.56
 Mm.341423 Dock4 Dedicator of cytokinesis 4 2.16 ± 0.05
 Mm.338001 Pld5 Phospholipase D family, member 5 1.90 ± 0.21
 Mm.33902 Igtp Interferon gamma induced GTPase 1.84 ± 0.26
 Mm.211477 Phldb2 Pleckstrin homology-like domain, family B, member 2 1.76 ± 0.13
 Mm.247453 Abhd10 Abhydrolase domain containing 10 1.50 ± 0.22
 Mm.6856 Pttg1 Pituitary tumor-transforming gene 1 1.46 ± 0.04
 Mm.290764 Lrrc61 Leucine rich repeat containing 61 1.43 ± 0.26
 Mm.442861 H2-D4 Histocompatibility 2, D region locus 4 1.40 ± 0.15
Genes uniquely modulated at 72 h pi
 Mm.141021 Ifitm3 Interferon induced transmembrane protein 3 2.98 ± 0.37
 Mm.425949 Ly6a Lymphocyte antigen 6 complex, locus A 2.64 ± 0.46
 Mm.44176 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 2.44 ± 0.17
 Mm.439743 H2-Q7 Histocompatibility 2, Q region locus 7 2.35 ± 0.13
 Mm.132226 Ehd4 EH-domain containing 4 2.05 ± 0.30
 Mm.41075 Drd4 Dopamine receptor 4 1.97 ± 0.15
 Mm.39825 Lmx1b LIM homeobox transcription factor 1 beta 1.84 ± 0.12
 Mm.131422 Osm Oncostatin M 1.67 ± 0.26
 Mm.475107 Rtp4 Receptor transporter protein 4 1.51 ± 0.10
 Mm.69751 Pepd Peptidase D 1.44 ± 0.11
Genes uniquely modulated at 96 h pi
 Mm.4950 Isg15 ISG15 ubiquitin-like modifier 4.04 ± 0.46
 Mm.425949 Ly6a Lymphocyte antigen 6 complex, locus A 3.89 ± 0.12
 Mm.284248 Ccl5 Chemokine (C-C motif) ligand 5 3.76 ± 0.69
 Mm.290320 Ccl2 Chemokine (C-C motif) ligand 2 2.80 ± 0.25
 Mm.24045 Rsad2 Radical S-adenosyl methionine domain containing 2 2.74 ± 0.57
 Mm.133342 Rnf213 Ring finger protein 213 2.66 ± 0.37
 Mm.24125 Col4a3bp Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 2.59 ± 0.43
 Mm.426537 LOC100041885 PREDICTED: similar to C130026I21Rik protein 2.45 ± 0.19
 Mm.439648 H2-T23 Histocompatibility 2, T region locus 23 2.32 ± 0.44
 Mm.357727 Gm46 PREDICTED: gene model 46, (NCBI) 2.31 ± 0.23
  1. Genes that were uniquely modulated against V3000 infection in the brain were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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