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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

Fig. 3

Staining for VEEV antigen in the brain following infection with V3000 or V3034 strains of VEEV. Brain sections from animals infected with V3000 and V3034 were stained with VEEV-specific antibody to detect the presence of virus in the brain. (a) V3000 at 24 h, (b) V3034 at 24 h, (c) V3000 at 48 h, (d) V3034 at 48 h, (e) V3000 at 72 h, (f) V3034 at 72 h, (g) V3000 at 96 h and (h) V3034 at 96 h. At 48 h pi olfactory lobe (insert) showed positive staining for VEEV. Both the viruses showed positive VEEV staining (arrows) by 72 h pi. V3000 resulted in a more widespread staining in various regions of the brain which increased from 72 h to 96 h pi (hypothalamus shown here). In V3034 infected group at 96 h pi, one brain section showed VEEV staining only in the thalamus region (shown here) and one showed VEEV staining only in the olfactory lobe. Rest of the brain regions and sections were negative for VEEV staining after V3034 infection. Magnification: 20X

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