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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

Fig. 1

Histology of the spleen following infection with V3000 or V3034 strains of VEEV. Spleen sections were analyzed by H&E staining (a) V3000 at 24 h (4X), (b) V3000 at 48 h (4X), (c) V3000 at 72 h (4X), (d) V3034 at 24 h (4X), (e) V3034 at 48 h (4X), (f) V3034 at 72 h (4X), (g) V3000 at 24 h (20X), (h) V3000 at 48 h (20X), (i) V3000 at 72 h (20X), (j) V3034 at 24 h (20X), (k) V3034 at 48 h (20X), (l) V3034 at 72 h (20X), (m) Saline (4X) and (n) Saline (20X). Spleens from saline-injected control animals showed normal red and white pulp area (thin arrows). Spleens from V3000 or V3034 infected mice exhibited germinal center activity (black arrow heads), which was more extensive in V3000 infected mice compared to V3034 infection. A starry sky pattern (indicated by red arrows) due to increased apoptosis was apparent with V3000 infection. EMH (white arrow head) was observed in V3034 infected spleens unlike V3000 at 72 h

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