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Table 4 Comparison between S-NS and N-NS in comorbidities and serum biochemical parameters

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

 

S-NS (n=191)

n (%)

N-NS (n=179)

n (%)

P a

S-NS

P b

P c

Confirmed (n=123) n (%)

Probable (n=68) n(%)

Comorbidities

 Other CNS infectionsd

3 (1.6)

0

0.249

3 (2.4)

0

0.067

n.a.

 Brain injury

7 (3.7)

5 (2.8)

0.636

6 (4.9)

1 (1.5)

0.364

1.0

 Brain tumors

2 (1.0)

3 (1.7)

0.676

1 (0.8)

1 (1.5)

0.648

1.0

 Psychiatric disorders

12 (6.3)

2 (1.1)

0.009

7 (5.7)

5 (7.4)

0.034

0.018

 History of ischemic stroke

36 (18.8)

24 (13.4)

0.156

19 (15.4)

17 (25.0)

0.618

0.029

 History of hemorrhagic stroke

0

4 (2.2)

0.054

0

0

0.148

0.578

 Hypertension

83 (43.5)

85 (47.5)

0.436

47 (38.2)

36 (52.9)

0.110

0.444

 Heart diseasese

32 (16.8)

33 (18.4)

0.671

19 (15.4)

13 (19.1)

0.499

0.902

 Diabetes mellitus

59 (30.9)

40 (22.3)

0.064

37 (30.1)

22 (32.4)

0.130

0.105

 Chronic alcoholism

5 (2.6)

1 (0.6)

0.216

5 (4.1)

0

0.043

1.0

Serum biochemical parameters

 Elevated FPG (≥7.0 mmol/L)

38 (19.9)

24 (13.4)

0.095

30 (24.4)

8 (11.8)

0.014

0.731

 Elevated HbA1c (≥6.5%)

36 (28.3)

29 (25.4)

0.612

22 (27.2)

14 (30.4)

0.787

0.519

 Elevated CKf(male ≥308, female ≥192 U/L)

30 (16.9)

11 (6.6)

0.003

19 (17.0)

11 (16.9)

0.006

0.017

 Elevated HCYg

42 (32.1)

22 (18.3)

0.013

25 (32.9)

17 (30.9)

0.020

0.063

 Elevated TG (≥1.70 mmol/L)

41 (22.3)

41 (24.6)

0.616

22 (18.6)

19 (28.8)

0.237

0.505

 Elevated CHOL (≥6.22 mmol/L)

8 (4.3)

11 (6.6)

0.355

3 (2.5)

5 (7.6)

0.120

0.778

 Elevated ALT (male ≥50, female ≥40 U/L)

14 (7.3)

16 (9.0)

0.560

11 (8.9)

3 (4.4)

0.989

0.229

 Elevated AST (male ≥40, female ≥35 U/L)

21 (11.1)

15 (8.5)

0.407

16 (13.0)

5 (7.5)

0.205

0.797

 Elevated TBIL (≥17.1 μmol/L)

34 (18.1)

26 (15.0)

0.436

23 (18.9)

11 (16.7)

0.385

0.754

 Elevated BUN (≥8.2 mmol/L)

8 (4.2)

12 (6.7)

0.285

6 (4.9)

2 (2.9)

0.510

0.361

 Elevated sCr (male ≥115, female ≥97 μmol/L)

6 (3.1)

12 (6.7)

0.111

2 (1.6)

4 (5.9)

0.039

1.0

  1. S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, CNS central nervous system, FPG fasting plasma glucose, HbA1c glycated hemoglobin (A1c), CK creatine kinase, HCY homocysteine, TG triglyceride, CHOL cholesterol, ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, BUN blood urea nitrogen, sCr serum creatinine
  2. P a Comparison between the S-NS group and the N-NS group, P b Comparison between the confirmed neurosyphilis subgroup and the N-NS group, P c Comparison between the probable neurosyphilis subgroup and the N-NS group
  3. dTwo patients had viral encephalitis and one patient had viral meningitis before being diagnosed with S-NS
  4. eHeart diseases includes coronary heart disease, hypertensive heart disease, valvular heart disease and cardiac arrhythmia
  5. fOne patient with acute myocardial infarction was excluded
  6. gHomocysteine ≥15 μmol/L in male or ≥12 μmol/L in female in <60 age group, or ≥20 μmol/L in ≥60 age group
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BMC Infectious Diseases

ISSN: 1471-2334

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