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Table 1 Clinical characteristics of the study participants

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

 

N-NS (n=179)

S-NS (n=191)

P a

S-NS

P b

P c

P d

Confirmed (n=123)

Probable (n=68)

Male

112 (62.6%)

149 (78.0%)

0.001

97 (78.9%)

52 (76.5%)

0.702

0.003

0.039

 

P50 (P25-P75)e

P50 (P25-P75)

 

P50 (P25-P75)

P50 (P25-P75)

   

Age

54 (45-64)

53 (46-61)

0.661

52 (46-60)

55 (45-64)

0.373

0.474

0.869

Serum RPR titer

1:1 (Negative-1:2)

1:16 (1:4-1:64)

<0.001

1:32 (1:16-1:64)

1:2 (1:1-1:8)

<0.001

<0.001

<0.001

Serum TPPA titer

1:640 (1:320-1:1280)

1:10240 (1:2560-1:20480)

<0.001

1:20480 (1:10240-1:20480)

1:2560 (1:1280-1:5120)

<0.001

<0.001

<0.001

CSF RPR titer

Negative

1:2 (Negative-1:4)

<0.001

1:4 (1:2-1:8)

Negative

<0.001

<0.001

1.0

CSF TPPA titer

Negative

1:1280 (1:160-1:5120)

<0.001

1:5120 (1:1280-1:10240)

1:80 (1:80-1:640)

<0.001

<0.001

<0.001

CSF leukocyte (cells/μL)

4 (2-7)

15 (6-48)

<0.001

29 (12-59)

6 (2-13)

<0.001

<0.001

0.015

CSF protein (mg/L)

390.9 (289.9-540.0)

606.0 (418.6-884.3)

<0.001

733.9 (502.0-1025.0)

443.1 (325.8-607.2)

<0.001

<0.001

0.183

CSF albumin (mg/L)

249.0 (173.7-361.9)

296.4 (220.0-456.2)

0.003

296.4 (243.0-500.6)

297.0 (182.7-446.2)

0.218

0.001

0.204

CSF glucose (mmol/L)

3.70 (3.40-4.20)

3.54 (3.21-4.19)

0.037

3.48 (3.12-4.08)

3.74 (3.25-4.20)

0.030

0.003

0.913

CSF chloride (mmol/L)

124.3 (121.9-126.4)

124.4 (121.5-126.3)

0.696

124.8 (121.5-126.5)

123.9 (121.6-125.9)

0.303

0.902

0.330

CSF lactate (mmol/L)

1.76 (1.57-2.02)

1.89 (1.67-2.17)

0.043

1.90 (1.73-2.30)

1.83 (1.66-2.06)

0.160

0.018

0.516

CSF lactate dehydrogenase (U/L)

20.2 (16.7-27.7)

20.2 (16.0-26.5)

0.696

19.5 (16.0-23.6)

22.2 (17.8-34.1)

0.032

0.131

0.184

Intracranial pressure (mmH2O)

135 (110-160)

140 (110-160)

0.604

140 (110-160)

140 (100-160)

0.882

0.656

0.692

  1. N-NS syphilis/non-neurosyphilis, S-NS symptomatic neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CSF cerebrospinal fluid, P a Comparison between the S-NS group and the N-NS group, P b Comparison between the confirmed neurosyphilis subgroup and the probable neurosyphilis subgroup, P c Comparison between the confirmed neurosyphilis subgroup and the N-NS, P d Comparison between the probable neurosyphilis subgroup and the N-NS
  2. eData with skewed distribution was described using median (interquartile range)